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	Tumor targeted nanoparticle drug delivery system from partial VAR2CSA peptide conjugatedN-2-hydroxypropyl trimethyl ammonium chloride chitosan
	Guogang Cheng; Dan Li; Jinyu Han; Jie Chen; Baobei Wang; Mengxia Li; Tianxia Xiao; Kai Zhao; Xiujun Fan
	2016
会议名称	The 4th SKLRB Symposium on Reproductive Biology
会议地点	中国北京
英文摘要	To efficiently deliver anti-cancer drug to tumor site and reduce its toxic side effects on normal tissues, the partial VAR2CSA peptide decorated and tumor microenvironment triggering cascade pH-responsive chitosan derivative drug delivery system was fabricated. A cationic polymer N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC) and VAR2CSA-N-2-hydroxypropyl trimethyl ammonium chloride chitosan (CSA-N-2-HACC) were synthesized and characterized. And VAR2CSA peptide is served as targeting peptide for nanoparticles that can be specifically binds a distinct type chondroitin sulfate expressed in the placenta and most type of tumors. Strain HDZK-BYSB107 prodigiosin/CSA-N-2-HACC- nanoparticles (PG/CSA-N-2-HACC-NPs) were prepared by ionic-crosslinking method with carboxymethyl chitosan and then characterized according to morphology, size, and zeta potential. PG/CSA-N-2-HACC-NPs presented pH-triggered drug release behavior under acidic conditions. The accumulation of nanoparticles detected by laser confocal fluorescence microscopy and flow cytometry showed that CSA-N-2-HACC-NPs was easily taken up by JEG-3, PC-3, and A549 cells. CCK-8 assays studies revealed that cell viability was significantly inhibited by PG/CSA-N-2-HACC-NPs. More importantly, in vivo animal studies showed that PG/CSA-N-2-HACC-NPs exhibited better anti-tumor activity and lower toxic effect in subcutaneous choriocarcinoma, prostate, and non-small-cell lung cancer models compared with other groups. These results suggested that PG/CSA-N-2-HACC-NPs had better cancer targeting capacity and superior anti-tumor efficacy. Thus, this nanparticles delivery system has great potential as a novel carrier in delivering anti-tumor drugs.
收录类别	其他
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10831]
专题	深圳先进技术研究院_医药所
作者单位	2016
推荐引用方式 GB/T 7714	Guogang Cheng,Dan Li,Jinyu Han,et al. Tumor targeted nanoparticle drug delivery system from partial VAR2CSA peptide conjugatedN-2-hydroxypropyl trimethyl ammonium chloride chitosan[C]. 见:The 4th SKLRB Symposium on Reproductive Biology. 中国北京.

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