| Synthesis and Biological Characterization of Myristic Acid-Conjugated Thymopentin Analogs | |
| Yuanyan Tan; Wei Wang; Chunlei Wu; Zhengyin Pan; Guiyang Yao; Lijing Fang; Wu Su | |
| 2015 | |
| 会议名称 | 2015年全国药物化学学术会议暨第五届中英药物化学学术会议（CMCS2015） |
| 会议地点 | Lanzhou, China |
| 英文摘要 | Controlled release of peptides by plasma albumin is a successful strategy to extend half-life and improve their therapeutic effects. The short plasma half-life of thymopentin (TP5) has dramatically limited its clinical application for immunodeficiency diseases. Herein, a TP5 derivative was prepared by conjugating myristic acid at the C-terminal (TP5-MA). TP5-MA showed well preserved biological characteristics and significant longer elimination half-life in human plasma compared with TP5. Cytotoxicity test revealed that TP5-MA had a relatively low toxicity to spleen lymphocytes. Furthermore, the protracted immunomodulating effect was confirmed by the immunodepression rat model with subcutaneous injections of TP5-MA. It highly enhanced pharmacokinetic and pharmacodynamic properties without significant toxicity at the clinic dosage, expecting to broaden the potential clinical application of TP5-MA |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 内容类型 | 会议论文 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7458]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Yuanyan Tan,Wei Wang,Chunlei Wu,et al. Synthesis and Biological Characterization of Myristic Acid-Conjugated Thymopentin Analogs[C]. 见:2015年全国药物化学学术会议暨第五届中英药物化学学术会议（CMCS2015）. Lanzhou, China. |
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