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	Tumor-Targeting and Hyaluronidase Activatable Nanoparticles for Tumor Tracer and Photochemistry Therapy
	Wenjun Li; Zhengyin Pan; Cuifang Zheng; Peng Liu; Pengfei Zhang; Lintao Cai
	2015
会议名称	ChinaNanomedicine 2015
会议地点	Hangzhou, China
英文摘要	Novel tumor-targeting hyaluronidase activatable nanoparticles have been prepared by covalent attachment of hydrophobic chlorin e6 to hyaluronic acid (HA). DOX encapsulating the nanoparticles(HA-Ce6) showed stable nano-structure(sub-100 nm size distribution)in aqueous condition and rapid uptake into tumor cells. The resulting nanoparticles HA-Ce6(DOX) could efficiently reach the tumor tissue via the passive targeting strategies and specifically enter tumor cells through the receptor-mediated endocytosis based on CD44, the HA receptor on the surface of tumor cells. Under low dose of laser power and anti-cancer drug (DOX) conditions, in vitro and in vivo studies demonstrated more effective suppression of tumor growth than free Ce6 or free DOX, which also led to overcoming the drug resistance in cancer cells. In particular, Ce6 could generate fluorescence, which showed good near-infrared fluorescence imaging in the tumor-bearing mice. Overall, it was demonstrated that HA-Ce6(DOX) nanoparticles could be successfully applied to in vivo tumor imaging and photochemistry therapy simultaneously.
收录类别	其他
语种	英语
WOS记录号	WOS:000373923400359
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7441]
专题	深圳先进技术研究院_医药所
作者单位	2015
推荐引用方式 GB/T 7714	Wenjun Li,Zhengyin Pan,Cuifang Zheng,et al. Tumor-Targeting and Hyaluronidase Activatable Nanoparticles for Tumor Tracer and Photochemistry Therapy[C]. 见:ChinaNanomedicine 2015. Hangzhou, China.

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