Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats

	Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats
	Han, Xiuqing; Liu, Chunhua; Xue, Yong; Wang, Jingfeng; Xue, Changhu; Yanagita, Teruyoshi; Gao, Xiang; Wang, Yuming
刊名	BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
	2016
英文摘要	We investigated whether fatty liver preceded insulin resistance or vice versa using a long-term orotic acid(OA)-induced nonalcoholic fatty liver disease (NAFLD) model without the confounding effects of obesity and hyperlipidemia and explored the role of the liver in insulin resistance. Male Wistar rats were fed with or without OA supplementation for 30, 60, and 90days. The NAFLD group showed increased liver lipid at 30, 60, and 90days; glucose intolerance was noted at 60 and 90days. Furthermore, partial liver proteins and gene expressions related to upstream signaling of insulin were decreased. However, the liver glycogen content was elevated, and gluconeogenesis genes expressions were obviously decreased at 90days. The occurrence of fatty liver preceded insulin resistance in OA-induced NAFLD without the interference of obesity and hyperlipidemia, and hepatic insulin resistance may not play a conclusive role in insulinresistance in this model.
收录类别	SCI
原文出处	http://www.tandfonline.com/doi/abs/10.1080/09168451.2015.1123608
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10781]
专题	深圳先进技术研究院_医药所
作者单位	BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
推荐引用方式 GB/T 7714	Han, Xiuqing,Liu, Chunhua,Xue, Yong,et al. Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,2016.
APA	Han, Xiuqing.,Liu, Chunhua.,Xue, Yong.,Wang, Jingfeng.,Xue, Changhu.,...&Wang, Yuming.(2016).Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY.
MLA	Han, Xiuqing,et al."Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats".BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2016).