Treating psoriasis by targeting its susceptibility gene Rel

	Treating psoriasis by targeting its susceptibility gene Rel
	Fan, Tingting; Wang, Shaowen; Yu, Linjiang; Yi, Hugiang; Liu, Ruiling; Geng, Wenwen; Wan, Xiaochun; Ma, Yifan; Cai, Lintao; Chen, Youhai H.
刊名	CLINICAL IMMUNOLOGY
	2016
英文摘要	Psoriasis is a chronic inflammatory disorder of the skin. Accumulating evidence indicates that the Rel gene, a member of the NF-kappa B family, is a risk factor for the disease. We sought to investigate whetherpsoriasis can be prevented by directly targeting the Rel gene transcript, i.e., the c-Rel mRNA. Using chemically-modified c-Rel specific siRNA (siRel) and poly(ethylene glycol)-b-poly(L-lysine)-b-poly(L-leucine) (PEG-PLL-PLLeu) micelles, we successfully knocked down the expression of c-Rel, and showed that the expression of cytokine IL-23, a direct target of c-Rel that can drive the development of IL-17-producing T cells, was markedly inhibited. More importantly, treating mice with siRel not only prevented but also ameliorated imiquimod (IMQ)-induced psoriasis. Mechanistic studies showed that siRel treatment down-regulated the expression of multiple inflammatory cytokines. Taken together, these results indicate that thesusceptibility gene Rel can be targeted to treat and prevent psoriasis.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S1521661616300377
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10722]
专题	深圳先进技术研究院_医药所
作者单位	CLINICAL IMMUNOLOGY
推荐引用方式 GB/T 7714	Fan, Tingting,Wang, Shaowen,Yu, Linjiang,et al. Treating psoriasis by targeting its susceptibility gene Rel[J]. CLINICAL IMMUNOLOGY,2016.
APA	Fan, Tingting.,Wang, Shaowen.,Yu, Linjiang.,Yi, Hugiang.,Liu, Ruiling.,...&Ruan, Qingguo.(2016).Treating psoriasis by targeting its susceptibility gene Rel.CLINICAL IMMUNOLOGY.
MLA	Fan, Tingting,et al."Treating psoriasis by targeting its susceptibility gene Rel".CLINICAL IMMUNOLOGY (2016).