Communication between nitric oxide synthase and positively-charged surface and bone formation promotion

	Communication between nitric oxide synthase and positively-charged surface and bone formation promotion
	Zhang, Wei; Liu, Jun; Shi, Haigang; Yang, Kun; Wang, Pingli; Wang, Gexia; Liu, Na; Wang, Huaiyu; Ji, Junhui; Chu, Paul K.
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2016
英文摘要	Despite the effects on physiology of bone marrow mesenchymal stem cells (BMSCs) and bone tissue, biological signal communication between bone implants and them is seldom employed as a guidance to create an osteo-inductive interface. Herein, the positively-charged surface is constructed on bone implant from the perspective of mediation of nitric oxide synthase (NOS) expression to signal BMSCs osteo-differentiation. In vitro and in vivo results indicate that the propersurface potential on the positively charged surface affects NOS to express a high level of inducible nitric oxide synthase (iNOS) in three NOS isoforms of the contacted BMSCs, upregulates their osteogenetic expression, and ultimately foster new bone growth. However, an excessively high surface potential produces substantial immunomodulatory effects thereby offsetting the aforementioned advantages. This study demonstrates that fine-tuning of the positively-chargedsurface and proper utilization of the communication between NOS and bone implants promote bone formation. (C) 2016 Published by Elsevier B.V.
收录类别	SCI
原文出处	http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=T1nqhXTYWY4AFFx2KEn&page=1&doc=1
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10715]
专题	深圳先进技术研究院_医药所
作者单位	COLLOIDS AND SURFACES B-BIOINTERFACES
推荐引用方式 GB/T 7714	Zhang, Wei,Liu, Jun,Shi, Haigang,et al. Communication between nitric oxide synthase and positively-charged surface and bone formation promotion[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2016.
APA	Zhang, Wei.,Liu, Jun.,Shi, Haigang.,Yang, Kun.,Wang, Pingli.,...&Chu, Paul K..(2016).Communication between nitric oxide synthase and positively-charged surface and bone formation promotion.COLLOIDS AND SURFACES B-BIOINTERFACES.
MLA	Zhang, Wei,et al."Communication between nitric oxide synthase and positively-charged surface and bone formation promotion".COLLOIDS AND SURFACES B-BIOINTERFACES (2016).