Catalytic asymmetric inverse-electron-demand 1,3-dipolar cycloaddition of C, N-cyclic azomethine imines with azlactones: access to chiral tricyclic tetrahydroisoquinolines

	Catalytic asymmetric inverse-electron-demand 1,3-dipolar cycloaddition of C, N-cyclic azomethine imines with azlactones: access to chiral tricyclic tetrahydroisoquinolines
	Liu XH; Wang YJ; Yang DX; Zhang JL; Liu DS; Su W
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2016
英文摘要	Reported herein is a bifunctional-organocatalystmediated enantioselective inverse-electron-demand 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines with azlactones. The strategy provides concise access to enantioenriched C1-substituted tetrahydroisoquinolines featuring a pyrazolidinone scaffold. Moreover, the scalability and practical utility of this protocol was well demonstrated by employing a gram-scale reaction and some representative transformations.
收录类别	SCI
原文出处	http://onlinelibrary.wiley.com/doi/10.1002/ange.201602880/full
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10689]
专题	深圳先进技术研究院_医药所
作者单位	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
推荐引用方式 GB/T 7714	Liu XH,Wang YJ,Yang DX,et al. Catalytic asymmetric inverse-electron-demand 1,3-dipolar cycloaddition of C, N-cyclic azomethine imines with azlactones: access to chiral tricyclic tetrahydroisoquinolines[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016.
APA	Liu XH,Wang YJ,Yang DX,Zhang JL,Liu DS,&Su W.(2016).Catalytic asymmetric inverse-electron-demand 1,3-dipolar cycloaddition of C, N-cyclic azomethine imines with azlactones: access to chiral tricyclic tetrahydroisoquinolines.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Liu XH,et al."Catalytic asymmetric inverse-electron-demand 1,3-dipolar cycloaddition of C, N-cyclic azomethine imines with azlactones: access to chiral tricyclic tetrahydroisoquinolines".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016).