Towards theory driven structure elucidation of complex natural products: mandelalides and coibamide A

	Towards theory driven structure elucidation of complex natural products: mandelalides and coibamide A
	Snyder, Kevin M.; Sikorska, Justyna; Ye, Tao; Fang, Lijing; Su, Wu; Carter, Rich G.; McPhail, Kerry L.; Cheong, Paul H. -Y.
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2016
英文摘要	The effectiveness of computational tools in determining relative configurations of complex molecules is investigated, using natural products mandelalides A-D and coibamide A, towards a generalized recipe for the scientific community at large. Ultimately, continuing efforts in this vein will accelerate and strengthen relative structure elucidation of complex molecules, such as natural products. Molecular mechanics conformational search, quantum mechanical NMR chemical shift predictions, and DP4 analyses led to confirmation of the revised structures of mandelalides A-D and coibamide A. All chiral centers in the northern hemisphere of mandelalides A-D are inverted with respect to the originally proposed structures, in agreement with recent total syntheses of mandelalide A by Ye, Furstner & Carter. In the case of coibamide A, it was found that Fang & Su's revision, in which both the macrocycle [ MeAla(11)] and the side chain [HIV2] residues are inverted from L to D, was consistent with the authentic natural product and computations.
收录类别	SCI
原文出处	http://pubs.rsc.org/en/content/articlehtml/2016/ob/c6ob00707d
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10679]
专题	深圳先进技术研究院_医药所
作者单位	ORGANIC & BIOMOLECULAR CHEMISTRY
推荐引用方式 GB/T 7714	Snyder, Kevin M.,Sikorska, Justyna,Ye, Tao,et al. Towards theory driven structure elucidation of complex natural products: mandelalides and coibamide A[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2016.
APA	Snyder, Kevin M..,Sikorska, Justyna.,Ye, Tao.,Fang, Lijing.,Su, Wu.,...&Cheong, Paul H. -Y..(2016).Towards theory driven structure elucidation of complex natural products: mandelalides and coibamide A.ORGANIC & BIOMOLECULAR CHEMISTRY.
MLA	Snyder, Kevin M.,et al."Towards theory driven structure elucidation of complex natural products: mandelalides and coibamide A".ORGANIC & BIOMOLECULAR CHEMISTRY (2016).