Spectrin: Structure, function and disease

	Spectrin: Structure, function and disease
	Zhang Rui; Zhang ChenYu; Zhao Qi; Li DongHai
刊名	SCIENCE CHINA-LIFE SCIENCES
	2013
英文摘要	Spectrin is a large, cytoskeletal, and heterodimeric protein composed of modular structure of alpha and beta subunits, it typically contains 106 contiguous amino acid sequence motifs called "spectrin repeats". Spectrin is crucial for maintaining the stability and structure of the cell membrane and the shape of a cell. Moreover, it contributes to diverse cell functions such as cell adhesion, cell spreading, and the cell cycle. Mutations of spectrin lead to various human diseases such as hereditary hemolytic anemia, type 5 spinocerebellar ataxia, cancer, as well as others. This review focuses on recent advances in determining the structure and function of spectrin as well as its role in disease.
收录类别	SCI
原文出处	http://link.springer.com/article/10.1007/s11427-013-4575-0#page-1
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5191]
专题	深圳先进技术研究院_医药所
作者单位	SCIENCE CHINA-LIFE SCIENCES
推荐引用方式 GB/T 7714	Zhang Rui,Zhang ChenYu,Zhao Qi,et al. Spectrin: Structure, function and disease[J]. SCIENCE CHINA-LIFE SCIENCES,2013.
APA	Zhang Rui,Zhang ChenYu,Zhao Qi,&Li DongHai.(2013).Spectrin: Structure, function and disease.SCIENCE CHINA-LIFE SCIENCES.
MLA	Zhang Rui,et al."Spectrin: Structure, function and disease".SCIENCE CHINA-LIFE SCIENCES (2013).