Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy

	Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy
	J. Mou; P. Liu; C. Liu; H. Xu; L. Song; J. Wang; K. Zhang; Y. Chen; J. Shi; H. Chen
刊名	Small
	2015
英文摘要	Monodisperse, ultrasmall (<5 nm) Cu 2− x S nanodots ( u -Cu 2− x S NDs) with signifi cantly strong near-infrared absorption and conversion are successfully demonstrated for effective deep-tissue photoacoustic imaging-guided photothermal therapy both in vitro and in vivo. Owing to ultrasmall nanoparticle size and high water dispersibility as well as long stability, such nanodots possess a prolonged circulation in blood and good passive accumulation within tumors through the enhanced permeability and retention effect. These u -Cu 2− x S NDs have negligible side effects to both blood and normal tissues according to in vivo toxicity evaluations for up to 3 months, showing excellent hemo/histocompatibility. Furthermore, these u -Cu 2− x S NDs can be thoroughly cleared through feces and urine within 5 days, showing high biosafety for further potential clinical translation. This novel photoacoustic imaging-guided photothermal therapy based on u -Cu 2− x S NDs composed of a single component shows great prospects as a multifunctional nanoplatform with integration and multifunction for cancer diagnosis and therapy.
收录类别	SCI
原文出处	onlinelibrary.wiley.com/doi/10.1002/smll.201403249/abstract
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7066]
专题	深圳先进技术研究院_医工所
作者单位	Small
推荐引用方式 GB/T 7714	J. Mou,P. Liu,C. Liu,et al. Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy[J]. Small,2015.
APA	J. Mou.,P. Liu.,C. Liu.,H. Xu.,L. Song.,...&H. Chen.(2015).Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy.Small.
MLA	J. Mou,et al."Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy".Small (2015).