PLGA/TCP composite scaffold incorporating bioactive phytomolecule icaritin for enhancement of bone defect repair in rabbits

	PLGA/TCP composite scaffold incorporating bioactive phytomolecule icaritin for enhancement of bone defect repair in rabbits
	S.-H. Chen; M. Lei; X.-H. Xie; L.-Z. Zheng; D. Yao; X.-L. Wang; W. Li; Z. Zhao; A. Kong; D.-M. Xiao
刊名	ACTA BIOMATERIALIA
	2013
英文摘要	Bone defect repair is challenging in orthopaedic clinics. For treatment of large bone defects, bone grafting remains the method of choice for the majority of surgeons, as it fills spaces and provides support to enhance biological bone repair. As therapeutic agents are desirable for enhancing bone healing, this study was designed to develop such a bioactive composite scaffold (PLGA/TCP/ICT) made of polylactide-co-glycolide (PLGA) and tricalcium phosphate (TCP) as a basic carrier, incorporating a phytomolecule icaritin (ICT), i.e., a novel osteogenic exogenous growth factor. PLGA/TCP/ICT scaffolds were fabricated as PLGA/TCP (control group) and PLGA/TCP in tandem with low/mid/high-dose ICT (LICT/MICT/HICT groups, respectively). To evaluate the in vivo osteogenic and angiogenic potentials of these bioactive scaffolds with slow release of osteogenic ICT, the authors established a 12 mm ulnar bone defect model in rabbits. X-ray and high-resolution peripheral quantitative computed tomography results at weeks 2, 4 and 8 post-surgery showed more newly formed bone within bone defects implanted with PLGA/TCP/ICT scaffolds, especially PLGA/TCP/MICT scaffold. Histological results at weeks 4 and 8 also demonstrated more newly mineralized bone in PLGA/TCP/ICT groups, especially in the PLGA/TCP/MICT group, with correspondingly more new vessel ingrowth. These findings may form a good foundation for potential clinical validation of this innovative bioactive scaffold incorporated with the proper amount of osteopromotive phytomolecule ICT as a ready product for clinical applications.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S1742706113000391
语种	英语
WOS记录号	WOS:000318199600041
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4901]
专题	深圳先进技术研究院_医工所
作者单位	ACTA BIOMATERIALIA
推荐引用方式 GB/T 7714	S.-H. Chen,M. Lei,X.-H. Xie,et al. PLGA/TCP composite scaffold incorporating bioactive phytomolecule icaritin for enhancement of bone defect repair in rabbits[J]. ACTA BIOMATERIALIA,2013.
APA	S.-H. Chen.,M. Lei.,X.-H. Xie.,L.-Z. Zheng.,D. Yao.,...&L. Qin.(2013).PLGA/TCP composite scaffold incorporating bioactive phytomolecule icaritin for enhancement of bone defect repair in rabbits.ACTA BIOMATERIALIA.
MLA	S.-H. Chen,et al."PLGA/TCP composite scaffold incorporating bioactive phytomolecule icaritin for enhancement of bone defect repair in rabbits".ACTA BIOMATERIALIA (2013).