Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

	Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety
	Wang GQ; Cen C; Li C; Cao S; Wang N; Zhou Z; Liu XM; Xu Y; Tian NX; Zhang Y
刊名	Nature Communications
	2015
英文摘要	The medial prefrontal cortex (mPFC) is implicated in processing sensory-discriminative and affective pain. Nonetheless, the underlying mechanisms are poorly understood. Here we demonstrate a role for excitatory neurons in the prelimbic cortex (PL), a sub-region of mPFC,in the regulation of pain sensation and anxiety-like behaviours. Using a chronic inflammatory pain model, we show that lesion of the PL contralateral but not ipsilateral to the inflamed paw attenuates hyperalgesia and anxiety-like behaviours in rats. Optogenetic activation of contralateral PL excitatory neurons exerts analgesic and anxiolytic effects in mice subjected to chronic pain, whereas inhibition is anxiogenic in naive mice. The intrinsic excitability of contralateral PL excitatory neurons is decreased in chronic pain rats; knocking down cyclindependent kinase 5 reverses this deactivation and alleviates behavioural impairments.Together, our findings provide novel insights into the role of PL excitatory neurons in the regulation of sensory and affective pain.
收录类别	SCI
原文出处	http://www.nature.com/ncomms/2015/150716/ncomms8660/full/ncomms8660.html
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/6819]
专题	深圳先进技术研究院_脑所
作者单位	Nature Communications
推荐引用方式 GB/T 7714	Wang GQ,Cen C,Li C,et al. Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety[J]. Nature Communications,2015.
APA	Wang GQ.,Cen C.,Li C.,Cao S.,Wang N.,...&Wang Y*.(2015).Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety.Nature Communications.
MLA	Wang GQ,et al."Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety".Nature Communications (2015).