Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling.

	Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling.
	Fu WM; Zhu X; Wang WM; Lu YF; Hu BG; Wang H; Liang WC; Wang SS; Ko CH; Waye MM
刊名	JOURNAL OF HEPATOLOGY
	2015
英文摘要	In this study, we reported that Hotair negatively regulated miR-218 expression in HCC, which might be mediated through an EZH2-targeting-miR-218-2 promoter regulatory axis. Further investigation revealed that Hotair knockdown dramatically inhibited cell viability and induced G1-phase arrest in vitro and suppressed tumorigenicity in vivo by promoting miR-218 expression. Oncogene Bmi-1 was shown to be a functional target of miR-218, and the main downstream targets signaling, P16(Ink4a) and P14(ARF), were activated in Hotair-suppressed tumorigenesis. In primary human HCC specimens, Hotair and Bmi-1 were concordantly upregulated whereas miR-218 was downregulated in these tissues. Furthermore, Hotair was inversely associated with miR-218 expression and positively correlated with Bmi-1 expression in these clinical tissues.
收录类别	SCI
原文出处	http://ac.els-cdn.com/S0168827815003438/1-s2.0-S0168827815003438-main.pdf?_tid=ed06f548-98d5-11e5-a9c3-00000aacb35d&acdnat=1449048207_d8b305a9b677213cd5ae36084d1639f0
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7552]
专题	深圳先进技术研究院_南沙所
作者单位	JOURNAL OF HEPATOLOGY
推荐引用方式 GB/T 7714	Fu WM,Zhu X,Wang WM,et al. Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling.[J]. JOURNAL OF HEPATOLOGY,2015.
APA	Fu WM.,Zhu X.,Wang WM.,Lu YF.,Hu BG.,...&Zhang JF.(2015).Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling..JOURNAL OF HEPATOLOGY.
MLA	Fu WM,et al."Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling.".JOURNAL OF HEPATOLOGY (2015).