Assessment of Dynamic Cerebral Autoregulation in Patients with Basilar Artery Stenosis

	Assessment of Dynamic Cerebral Autoregulation in Patients with Basilar Artery Stenosis
	Gong Xiping; Liu Jia; Dong Pei; Zhang Pandeng; Li Na; Zhao Xingquan; Wang Yongjun
刊名	PLOS ONE
	2013
英文摘要	Background and Aims: Previous studies have shown impaired cerebral autoregulation (CA) in carotid and middle cerebral artery (MCA) stenosis/occlusion. Little is known about CA in patients with basilar artery (BA) stenosis. We therefore investigated dynamic CA patterns in BA stenosis using transfer function analysis (TFA). Methods: We measured spontaneous oscillations of blood flow velocity (CBFV) in the right posterior cerebral artery (PCA), and left MCA and mean arterial pressure (ABP) continuously in 25 patients with BA stenosis (moderate n=16 with 50-69% occlusion and severe n=9 with >= 70% occlusion) and 22 healthy volunteers in supine position during 6 circles per minute deep breath. Analysis was based on the 'black-box' model of transfer function deriving phase and gainin both PCA and MCA. Results: Though changes of phase shift and gain between the patients and healthy controls were observed in MCA, the differences are however not significant. Phase shift in PCA was significantly decreased in severe stenosis when comparing with healthy controls and moderate stenosis (4.2 +/- 34.2 degrees VS 41.1 +/- 40.4 degrees, 4.2 +/- 34.2 degrees VS 34.2 +/- 27.2 degrees, both p<0.05), whilst the gain in PCA is increased for moderate BA stenosis and decreased for severe BA stenosis. Furthermore, we found that phase shift were almost abolished in patients with ischemic stroke who developed unfavorable clinical outcome (mRs>2) on the 90 days after stroke onset. Conclusion: Dynamic CA in PCA reduces in patients with severe BA stenosis and those with ischemic stroke who present poor outcome in 90 days after stroke onset. Phase shift might be a sensitive index prompting impaired CA in posterior circulation.
收录类别	SCI
原文出处	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790759/
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4460]
专题	深圳先进技术研究院_集成所
作者单位	PLOS ONE
推荐引用方式 GB/T 7714	Gong Xiping,Liu Jia,Dong Pei,et al. Assessment of Dynamic Cerebral Autoregulation in Patients with Basilar Artery Stenosis[J]. PLOS ONE,2013.
APA	Gong Xiping.,Liu Jia.,Dong Pei.,Zhang Pandeng.,Li Na.,...&Wang Yongjun.(2013).Assessment of Dynamic Cerebral Autoregulation in Patients with Basilar Artery Stenosis.PLOS ONE.
MLA	Gong Xiping,et al."Assessment of Dynamic Cerebral Autoregulation in Patients with Basilar Artery Stenosis".PLOS ONE (2013).