High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues

CORC > 沈阳自动化研究所 > 中国科学院沈阳自动化研究所 > 机器人学研究室

	High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues
	Yang WG(杨文广); Yu HB(于海波); Wang YC(王越超); Liu LQ(刘连庆)
刊名	Small
	2017
卷号	13 期号:5 页码:1-11
ISSN号	1613-6810
通讯作者	于海波 ; 刘连庆
产权排序	1
中文摘要	3D hydrogel microstructures that encapsulate cells have been used in broad applications in microscale tissue engineering, personalized drug screening, and regenerative medicine. Recent technological advances in microstructure assembly, such as bioprinting, magnetic assembly, microfluidics, and acoustics, have enabled the construction of designed 3D tissue structures with spatially organized cells in vitro. However, a bottleneck exists that still hampers the application of microtissue structures, due to a lack of techniques that combined high-throughput fabrication and flexible assembly. Here, a versatile method for fabricating customized microstructures and reorganizing building blocks composed of functional components into a combined single geometric shape is demonstrated. The arbitrary microstructures are dynamically synthesized in a microfluidic device and then transferred to an optically induced electrokinetics chip for manipulation and assembly. Moreover, building blocks containing different cells can be arranged into a desired geometry with specific shape and size, which can be used for microscale tissue engineering.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	STOP-FLOW LITHOGRAPHY ; DIELECTROPHORETIC ODEP FORCE ; OPTOELECTRONIC TWEEZERS ; 2-PHOTON POLYMERIZATION ; MICROFLUIDIC PLATFORM ; PRINTING TECHNOLOGY ; DRUG-DELIVERY ; STEM-CELLS ; HYDROGELS ; MICROPARTICLES
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000397009300010
内容类型	期刊论文
源URL	[http://ir.sia.cn/handle/173321/19887]
专题	沈阳自动化研究所_机器人学研究室
推荐引用方式 GB/T 7714	Yang WG,Yu HB,Wang YC,et al. High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues[J]. Small,2017,13(5):1-11.
APA	Yang WG,Yu HB,Wang YC,&Liu LQ.(2017).High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues.Small,13(5),1-11.
MLA	Yang WG,et al."High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues".Small 13.5(2017):1-11.