Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability

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	Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability
	Xu, Ting 1,2,3,4; Opitz, Alexander 3,4; Craddock, R. Cameron 3,4; Wright, Margaret J.5,6; Zuo, Xi-Nian1,2 ; Milham, Michael P.3,4
刊名	CEREBRAL CORTEX
	2016-11-01
卷号	26 期号:11 页码:4192-4211
关键词	areal organization individual differences reliability resting-state fMRI transition zones
ISSN号	1047-3211
英文摘要	Resting state fMRI (R-fMRI) is a powerful in-vivo tool for examining the functional architecture of the human brain. Recent studies have demonstrated the ability to characterize transitions between functionally distinct cortical areas through the mapping of gradients in intrinsic functional connectivity (iFC) profiles. To date, this novel approach has primarily been applied to iFC profiles averaged across groups of individuals, or in one case, a single individual scanned multiple times. Here, we used a publically available R-fMRI dataset, in which 30 healthy participants were scanned 10 times (10 min per session), to investigate differences in full-brain transition profiles (i.e., gradient maps, edge maps) across individuals, and their reliability. 10-min R-fMRI scans were sufficient to achieve high accuracies in efforts to "fingerprint" individuals based upon full-brain transition profiles. Regarding test-retest reliability, the image-wise intraclass correlation coefficient (ICC) was moderate, and vertex-level ICC varied depending on region; larger durations of data yielded higher reliability scores universally. Initial application of gradient-based methodologies to a recently published dataset obtained from twins suggested inter-individual variation in areal profiles might have genetic and familial origins. Overall, these results illustrate the utility of gradient-based iFC approaches for studying inter-individual variation in brain function.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	FUNCTIONAL CONNECTIVITY ARCHITECTURE ; HUMAN CEREBRAL-CORTEX ; SURFACE-BASED ANALYSIS ; CORTICAL SURFACE ; INDIVIDUAL VARIABILITY ; COORDINATE SYSTEM ; DISCOVERY SCIENCE ; GENETIC-CONTROL ; FMRI DATA ; NETWORKS
收录类别	SCI
语种	英语
WOS记录号	WOS:000388532300007
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/20830]
专题	心理研究所_中国科学院行为科学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing 100101, Peoples R China 3.Child Mind Inst, Ctr Developing Brain, 445 Pk Ave, New York, NY 10022 USA 4.Nathan S Kline Inst Psychiat Res, Ctr Biomed Imaging & Neuromodulat, Orangeburg, NY 10962 USA 5.Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia 6.Univ Queensland, Ctr Adv Imaging, St Lucia, Qld 4072, Australia
推荐引用方式 GB/T 7714	Xu, Ting,Opitz, Alexander,Craddock, R. Cameron,et al. Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability[J]. CEREBRAL CORTEX,2016,26(11):4192-4211.
APA	Xu, Ting,Opitz, Alexander,Craddock, R. Cameron,Wright, Margaret J.,Zuo, Xi-Nian,&Milham, Michael P..(2016).Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability.CEREBRAL CORTEX,26(11),4192-4211.
MLA	Xu, Ting,et al."Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability".CEREBRAL CORTEX 26.11(2016):4192-4211.