mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 重大疾病机理的遗传学

	mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia
	Li H 1,6; Bi R 2; Li ZC 1; He Y 1; Zhou J 1; Tang JS 1; Chen XG[]1; Yao YG[]2,3,5; Fan Y 2; Wu Y 2,3
刊名	Molecular Neurobiology
	2016
卷号	期号:页码:published online
关键词	Heteroplasmy Monozygotic twins Schizophrenia mtDNA
通讯作者	tangjinsonghn@gmail.com
合作状况	其它
英文摘要	Although monozygotic (MZ) twins have theoretically identical nuclear DNA sequences, there may be phenotypic differences between them caused by somatic mutations and epigenetic changes affecting each genome. In this study, we collected eight families of MZ twins discordant for schizophrenia with the aim of investigating the potential role of mitochondrial DNA (mtDNA) heteroplasmy in causing the phenotypic differences between the twin pairs. Next-generation sequencing (NGS) technology was used to screen the whole mitochondrial genome of the twin pairs and their parents. The mtDNA heteroplasmy level was found to be nearly identical between the twin pairs but was distinctly different between each mother and their offspring. These results suggest that the discordance of schizophrenia between MZ twins may not be attributable to the difference in mtDNA heteroplasmy, and the high concordance of mtDNA heteroplasmy between MZ twins may indicate the relatively equal distribution of mtDNA during embryo separation of MZ twins and/or the modulation effect from the same nuclear genetic background. Furthermore, we observed an overrepresentation of heteroplasmy in noncoding regions and an elevated ratio of nonsynonymous heteroplasmy, suggesting the possible effects of a purifying selection in shaping the pattern of mtDNA heteroplasmy.
收录类别	SCI
资助信息	This study was supported by the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02020003), the National Natural Science Foundation of China (31171225, 81271484, 81471361, and 81371480), and the National Key Basic Research and Development Program (973) (Grant No. 2012CB517904).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10223]
专题	昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Institute of Mental Health of the Second Xiangya Hospital ofCentral South University, The China National Clinical Research Center for Mental Health Disorders, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, Hunan 410011, China 2.Key Laboratory ofAnimal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China 4.Department of Psychiatry, the First Affiliated Hospital of China Medical University, Shenyang 110122, China 5.CAS Center for Excellence in Brain Science and Intelligence Technology,ChineseAcademyofSciences,Shanghai200031,China 6.Department of Psychiatry, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
推荐引用方式 GB/T 7714	Li H,Bi R,Li ZC,et al. mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia[J]. Molecular Neurobiology,2016,():published online.
APA	Li H.,Bi R.,Li ZC.,He Y.,Zhou J.,...&Tang YQ[].(2016).mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia.Molecular Neurobiology,(*),published online.
MLA	Li H,et al."mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia".Molecular Neurobiology .(2016):published online.