Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term depression in the CA1 region of the hippocampal slice

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term depression in the CA1 region of the hippocampal slice
	Zhang JC 1; Yang Y 1; Li HB 1; Cao J[]1; Xu L[]1,2
刊名	BRAIN RESEARCH
	2005
卷号	1050 期号:1-2 页码:110-117
关键词	synaptic plasticity long-term depression long-term potentiation miniature EPSC hippocampus metaplasticity
通讯作者	juncao@vip.163.com ; lxu@vip.163.com
英文摘要	Prior synaptic or cellular activity influences degree or threshold for subsequent induction of synaptic plasticity, a process known as metaplasticity. Thus, the continual synaptic activity, spontaneous miniature excitatory synaptic current (mEPSC) may correlate to the induction of long-teen depression (LTD). Here, we recorded whole-cell EPSC and mEPSC alternately in the Schaffer-CA1 synapses in brain slice of young rats, and found that this recording configuration affected neither EPSC nor mEPSC. Low frequency stimulation (LFS) induced variable magnitudes of LTD. Remarkably, larger magnitudes of LTD were significantly correlated to smaller amplitude/lower frequency of the basal mEPSC. Furthermore, under the conditions reduced amplitude/frequency of the basal mEPSC by exposure to behavioral stress immediately before slice preparation or low concentration of calcium in bath solution, the magnitudes of LTD were still inversely correlated to mEPSC amplitude/frequency. These new findings suggest that spontaneous mEPSC may reflect functional and/or structural aspects of the synapses, the synaptic history ongoing metaplasticity.
收录类别	SCI
资助信息	This work was supported by grants from the Chinese Academy of Sciences (KSCX2-SW-04) and the National Science Foundation of China (30470549) to L.X.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10888]
专题	昆明动物研究所_学习记忆的分子神经机制
作者单位	1.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223 and Graduate School of The Chinese Academy of Sciences, Beijing 100039, PR China 2.Mental Health Institute of the 2nd Hospital of Xiangya Medical College, Central South University, Changsha 410011, PR China
推荐引用方式 GB/T 7714	Zhang JC,Yang Y,Li HB,et al. Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term depression in the CA1 region of the hippocampal slice[J]. BRAIN RESEARCH,2005,1050(1-2):110-117.
APA	Zhang JC,Yang Y,Li HB,Cao J[],&Xu L[].(2005).Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term depression in the CA1 region of the hippocampal slice.BRAIN RESEARCH,1050(1-2),110-117.
MLA	Zhang JC,et al."Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term depression in the CA1 region of the hippocampal slice".BRAIN RESEARCH 1050.1-2(2005):110-117.