Chronic constant light-induced hippocampal late-phase long-term potentiation impairment in vitro is attenuated by antagonist of D1/D5 receptors

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Chronic constant light-induced hippocampal late-phase long-term potentiation impairment in vitro is attenuated by antagonist of D1/D5 receptors
	Chai AP 1,2; Ma WP 1; Wang LP 1; Cao J 1; Xu L 1; Yang YX[]1; Mao RR[]1
刊名	BRAIN RESEARCH
	2015
卷号	1622 期号:X 页码:72-80
关键词	Circadian rhythm disruption D1/D5 receptors Hippocampus Long-term potentiation
通讯作者	yangyx@mail.kiz.ac.cn ; talktomaomao@163.com
合作状况	其它
英文摘要	Previous study reported that chronic constant light exposure caused hippocampus-dependent long-term memory deficit. However, the underlying cellular mechanism of this impairment is still unclear. Multiple lines of evidence indicated that long-term potentiation (LTP) is a cellular model for memory formation. Here we found that, by recording of field excitatory postsynaptic potential (fEPSP) in vitro, chronic constant light (CCL, 3 weeks) exposure impaired the late long-term potentiation (L-LTP), but not early long-term potentiation (E-LTP) and basal transmission in Schaffer collateral (SC)-CA1 synapses of hippocampal slices from rats. Because L-LTP depends on D1/D5 receptors, we examined whether interference of D1/D5 receptors can modulate L-LTP of CCL rats. Bath application of D1/D5 receptors antagonist SCH23390 (1μM) blocked L-LTP in control rats and attenuated the impaired L-LTP in CCL rats. In contrast, pre-incubation of D1/D5 receptors agonist SKF38393 (25μM) occluded further L-LTP in control rats while exacerbated the L-LTP impairment in CCL rats. These results suggested that CCL-induced L-LTP impairment can be modulated by D1/D5 receptors. Our findings may contribute to the further understanding of synaptic plasticity mechanism underlying hippocampal long-term memory impairment induced by circadian rhythm disruption.
收录类别	SCI
资助信息	This work was supported by National Basic Program of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (31100786, 81171294, U1032605 and U1132602), and Science and Technology Program of Yunnan Province (2013GA003 and 2013FA048).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9372]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Chai AP,Ma WP,Wang LP,et al. Chronic constant light-induced hippocampal late-phase long-term potentiation impairment in vitro is attenuated by antagonist of D1/D5 receptors[J]. BRAIN RESEARCH,2015,1622(X):72-80.
APA	Chai AP.,Ma WP.,Wang LP.,Cao J.,Xu L.,...&Mao RR[*].(2015).Chronic constant light-induced hippocampal late-phase long-term potentiation impairment in vitro is attenuated by antagonist of D1/D5 receptors.BRAIN RESEARCH,1622(X),72-80.
MLA	Chai AP,et al."Chronic constant light-induced hippocampal late-phase long-term potentiation impairment in vitro is attenuated by antagonist of D1/D5 receptors".BRAIN RESEARCH 1622.X(2015):72-80.