Rapid-onset antidepressant efficacy of glutamatergic system modulators: The neural plasticity hypothesis of depression

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Rapid-onset antidepressant efficacy of glutamatergic system modulators: The neural plasticity hypothesis of depression
	Wang J 1,2,3; Jing L 1,2; Toledo-Salas JC 1; Xu L[*]1,2
刊名	NEUROSCIENCE BULLETIN
	2015
卷号	31 期号:1 页码:75-86
关键词	depression stress neural plasticity glutamatergic transmission monoamine-based antidepressant ketamine
通讯作者	lxu@vip.163.com
合作状况	其它
英文摘要	Depression is a devastating psychiatric disorder widely attributed to deficient monoaminergic signaling in the central nervous system. However, most clinical antidepressants enhance monoaminergic neurotransmission with little delay but require 4−8 weeks to reach therapeutic efficacy, a paradox suggesting that the monoaminergic hypothesis of depression is an oversimplification. In contrast to the antidepressants targeting the monoaminergic system, a single dose of the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine produces rapid (within 2 h) and sustained (over 7 days) antidepressant efficacy in treatment-resistant patients. Glutamatergic transmission mediated by NMDARs is critical for experience-dependent synaptic plasticity and learning, processes that can be modified indirectly by the monoaminergic system. To better understand the mechanisms of action of the new antidepressants like ketamine, we review and compare the monoaminergic and glutamatergic antidepressants, with emphasis on neural plasticity. The pathogenesis of depression may involve maladaptive neural plasticity in glutamatergic circuits that may serve as a new class of targets to produce rapid antidepressant effects.
收录类别	SCI
资助信息	The review was supported by the 973 Program of the Ministry of Science and Technology of China (2013CB835103); the Strategic Priority Research Program of the Chinese Academy of Science (XDB02020200); and the National 863 Project of China (2012AA022402).
语种	英语
WOS记录号	WOS:000349316700009
公开日期	2015-03-06
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8275]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China 2.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Chin 3.Kunming College of Life Science, University of the Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式 GB/T 7714	Wang J,Jing L,Toledo-Salas JC,et al. Rapid-onset antidepressant efficacy of glutamatergic system modulators: The neural plasticity hypothesis of depression[J]. NEUROSCIENCE BULLETIN,2015,31(1):75-86.
APA	Wang J,Jing L,Toledo-Salas JC,&Xu L[*].(2015).Rapid-onset antidepressant efficacy of glutamatergic system modulators: The neural plasticity hypothesis of depression.NEUROSCIENCE BULLETIN,31(1),75-86.
MLA	Wang J,et al."Rapid-onset antidepressant efficacy of glutamatergic system modulators: The neural plasticity hypothesis of depression".NEUROSCIENCE BULLETIN 31.1(2015):75-86.