Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour.

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 神经系统编码

	Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour.
	Qin DD[]1; Rizak J 1; Pan L 3; Yin Y 3; Hu XT[]1,2,4; Feng XL 1; Yang SC 1; Lv LB 2
刊名	SCIENTIFIC REPORTS
	2016
卷号	6 期号:X 页码:e30187
通讯作者	qindong108@163.com ; xthu@mail.kiz.ac.cn
英文摘要	Stress is associated with the onset of depressive episodes, and cortisol hypersecretion is considered a biological risk factor of depression. However, the possible mechanisms underlying stress, cortisol and depressive behaviours are inconsistent in the literature. This study examined the interrelationships among stress, cortisol and observed depressive behaviours in female rhesus macaques for the first time and explored the possible mechanism underlying stress and depressive behaviour. Female monkeys were video-recorded, and the frequencies of life events and the duration of huddling were analysed to measure stress and depressive behaviour. Hair samples were used to measure chronic cortisol levels, and the interactions between stress and cortisol in the development of depressive behaviour were further evaluated. Significant correlations were found between stress and depressive behaviour measures and between cortisol levels and depressive behaviour. Stress was positively correlated with cortisol levels, and these two factors interacted with each other to predict the monkeys' depressive behaviours. This finding extends the current understanding of stress/cortisol interactions in depression, especially pertaining to females.
收录类别	SCI
资助信息	This research was supported by the National Program for Key Basic Research Project (973 Programs 2015CB755605, 2012CB825500, 2012CBA01304, 2011CB707800), the Strategic Priority Research Program of CAS (XDB02020000), the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167), The Yunnan Provincial Project to Attract One-hundred Exceptional Talents From Overseas, the National High-tech R&D Program of China (863 Program 2012AA020701), the Natural Science Foundation of Yunnan Province of China (2010ZC218), and the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10340]
专题	昆明动物研究所_神经系统编码昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China 3.Department of Rehabilitation Medicine, the Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650021, China 4.CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China
推荐引用方式 GB/T 7714	Qin DD[*],Rizak J,Pan L,et al. Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour.[J]. SCIENTIFIC REPORTS,2016,6(X):e30187.
APA	Qin DD[].,Rizak J.,Pan L.,Yin Y.,Hu XT[].,...&Lv LB.(2016).Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour..SCIENTIFIC REPORTS,6(X),e30187.
MLA	Qin DD[*],et al."Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour.".SCIENTIFIC REPORTS 6.X(2016):e30187.