Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey

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	Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey
	Huang H 1,2; Ya JR 2,3; Tian CY 5; Ren H 3; Carlson S 6; Yu HL 1; Chen F[]7; Wang JH[]2; Wu Z 2,3; Wen CM 2,3
刊名	MEDICAL SCIENCE MONITOR
	2016
卷号	22 期号:X 页码:1752-1760
关键词	Bromocriptine Dopamine Haloperidol Prefrontal Cortex Sensory Gating
通讯作者	Fenger0802@163.com
英文摘要	Background: Sensory gating, often described as the ability to filter out irrelevant information that is repeated in close temporal proximity, is essential for the selection, processing, and storage of more salient information. This study aimed to test the effect of sensory gating under anesthesia in the prefrontal cortex (PFC) of monkeys following injection of bromocriptine, haloperidol, and phencyclidine (PCP). Material/Methods: We used an auditory evoked potential that can be elicited by sound to examine sensory gating during treatment with haloperidol, bromocriptine, and PCP in the PFC in the cynomolgus monkey. Scalp electrodes were located in the bilateral PFC and bilateral temporal, bilateral parietal, and occipital lobes. Administration of bromocriptine (0.313 mg/kg, 0.625 mg/kg, and 1.25 mg/kg), haloperidol (0.001 mg/kg, 0.01 mg/kg, and 0.05 mg/kg), and the N-methyl-D-aspartic acid receptor antagonist PCP (0.3 mg/kg) influenced sensory gating. Results: We demonstrated the following: (1) Administration of mid-dose bromocriptine disrupted sensory gating (N100) in the right temporal lobe, while neither low-dose nor high-dose bromocriptine impaired gating. (2) Low-dose haloperidol impaired gating in the right prefrontal cortex. Mid-dose haloperidol disrupted sensory gating in left occipital lobe. High-dose haloperidol had no obvious effect on sensory gating. (3) Gating was impaired by PCP in the left parietal lobe. Conclusions: Our studies showed that information processing was regulated by the dopaminergic system, which might play an important role in the PFC. The dopaminergic system influenced sensory gating in a dose-and region-dependent pattern, which might modulate the different stages that receive further processing due to novel information.
收录类别	SCI
资助信息	This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01)
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10300]
专题	昆明动物研究所_神经系统编码昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Second Department of Neurosurgery, First Affiliation Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, P.R. China 3.Department of Neurology, First Affiliation Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China 4.Department of Neurosurgery, First Affiliation Hospital of Nanchang University, Nanchang, Jiangxi, P.R. China 5.Hainan Jingang Biological Technology Co., Ltd., Haikou, Hainan, P.R. China 6.Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland 7.Department of Radiology, People’s Hospital of Hainan, Haikou, Hainan, P.R. China
推荐引用方式 GB/T 7714	Huang H,Ya JR,Tian CY,et al. Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey[J]. MEDICAL SCIENCE MONITOR,2016,22(X):1752-1760.
APA	Huang H.,Ya JR.,Tian CY.,Ren H.,Carlson S.,...&Zheng SY.(2016).Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey.MEDICAL SCIENCE MONITOR,22(X),1752-1760.
MLA	Huang H,et al."Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey".MEDICAL SCIENCE MONITOR 22.X(2016):1752-1760.