Somatosensory Cortices Are Required for the Acquisition of Morphine-Induced Conditioned Place Preference

	Somatosensory Cortices Are Required for the Acquisition of Morphine-Induced Conditioned Place Preference
	Meng ZQ 1,2,3; Liu C 2,3; Hu XT[]1,5; Ma YY[]2,4,5
刊名	PLOS ONE
	2009
卷号	4 期号:11 页码:e7742
通讯作者	xthu@mail.kiz.ac.cn ; yuanma0716@vip.sina.com
英文摘要	Background: Sensory system information is thought to play an important role in drug addiction related responses. However, how somatic sensory information participates in the drug related behaviors is still unclear. Many studies demonstrated that drug addiction represents a pathological usurpation of neural mechanisms of learning and memory that normally relate to the pursuit of rewards. Thus, elucidate the role of somatic sensory in drug related learning and memory is of particular importance to understand the neurobiological mechanisms of drug addiction. Principal Findings: In the present study, we investigated the role of somatosensory system in reward-related associative learning using the conditioned place preference model. Lesions were made in somatosensory cortices either before or after conditioning training. We found that lesion of somatosensory cortices before, rather than after morphine conditioning impaired the acquisition of place preference. Conclusion: These results demonstrate that somatosensory cortices are necessary for the acquisition but not retention of morphine induced place preference.
收录类别	SCI
资助信息	This study was supported by National Science Foundation of China (NSFC 30470553, 30770700, 30530270); 863 program (O7013810,2006AA02A116); 973 program (2005CB522803, 2007CB947703); Yunnan Science and Technique Program (2006PT08-2). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9617]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_神经系统编码昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Laboratory of Sensory-motor Integration Research and State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China 2.Laboratory of Primate Cognitive Neuroscience and State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China 3.Graduate University of the Chinese Academy of Sciences, Beijing, People’s Republic of China 4.Kunming Primate Recearch Center, the Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China 5.Kunming Biomed International, Kunming, Yunnan, People’s Republic of China
推荐引用方式 GB/T 7714	Meng ZQ,Liu C,Hu XT[*],et al. Somatosensory Cortices Are Required for the Acquisition of Morphine-Induced Conditioned Place Preference[J]. PLOS ONE,2009,4(11):e7742.
APA	Meng ZQ,Liu C,Hu XT[],&Ma YY[].(2009).Somatosensory Cortices Are Required for the Acquisition of Morphine-Induced Conditioned Place Preference.PLOS ONE,4(11),e7742.
MLA	Meng ZQ,et al."Somatosensory Cortices Are Required for the Acquisition of Morphine-Induced Conditioned Place Preference".PLOS ONE 4.11(2009):e7742.