Rhesus monkey brain development during late infancy and the effect of phencyclidine: A longitudinal MRI and DTI study

	Rhesus monkey brain development during late infancy and the effect of phencyclidine: A longitudinal MRI and DTI study
	Liu CR 2,3; Tian XG 4,5; Liu HL 1; Mo Y 6; Bai F 1; Zhao XD 7; Ma YY 1,7,8; Wang JH[*]1
刊名	NEUROIMAGE
	2015
卷号	107 期号:X 页码:65-75
关键词	Infant Neurodevelopment Primates Template Phencyclidine
通讯作者	wjh16@hotmail.com
合作状况	其它
英文摘要	Early brain development is a complex and rapid process, the disturbance of which may cause the onset of brain disorders. Based on longitudinal imaging data acquired from 6 to 16 months postnatal, we describe a systematic trajectory of monkey brain development during late infancy, and demonstrate the influence of phencyclidine (PCP) on this trajectory. Although the general developmental trajectory of the monkey brain was close to that of the human brain, the development in monkeys was faster and regionally specific. Gray matter volume began to decrease during late infancy in monkeys, much earlier than in humans in whom it occurs in adolescence. Additionally, the decrease of gray matter volume in higher-order association regions (the frontal, parietal and temporal lobes) occurred later than in regions for primary functions (the occipital lobe and cerebellum). White matter volume displayed an increasing trend in most brain regions, but not in the occipital lobe, which had a stable volume. In addition, based on diffusion tensor imaging, we found an increase in fractional anisotropy and a decrease in diffusivity, which may be associated with myelination and axonal changes in white matter tracts. Meanwhile, we tested the influence of 14-day PCP treatment on the developmental trajectories. Such treatment tended to accelerated brain maturation during late infancy, although not statistically significant. These findings provide comparative information for the understanding of primate brain maturation and neurodevelopmental disorders.
收录类别	SCI
资助信息	This work was supported by 973 program (2012CB825500, 2011CB707800), NSFC (31271168, 91132307/H09, 61178051) and NSFC Finnish-Chinese joint project 813111172.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9248]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_神经系统编码
作者单位	1.Laboratory of the Primate Model for Brain Diseases and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Chi 2.The University of Queensland, Queensland Brain Institute, QLD 4072, Australia 3.Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, the Chinese Academy of Sciences, Beijing 100190, China 4.Graduate School of Neural and Behavioral Sciences, International Max Planck Research School, Tuebingen, 72074, Germany 5.Werner Reichardt Centre for Integrative Neuroscience, Tuebingen, 72076, Germany 6.Department of Medical Imaging, the First Affiliated Hospital of Kunming Medical University, Kunming 650223, China 7.State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 8.Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Liu CR,Tian XG,Liu HL,et al. Rhesus monkey brain development during late infancy and the effect of phencyclidine: A longitudinal MRI and DTI study[J]. NEUROIMAGE,2015,107(X):65-75.
APA	Liu CR.,Tian XG.,Liu HL.,Mo Y.,Bai F.,...&Wang JH[*].(2015).Rhesus monkey brain development during late infancy and the effect of phencyclidine: A longitudinal MRI and DTI study.NEUROIMAGE,107(X),65-75.
MLA	Liu CR,et al."Rhesus monkey brain development during late infancy and the effect of phencyclidine: A longitudinal MRI and DTI study".NEUROIMAGE 107.X(2015):65-75.