Irregular morphine administration affects the retention but not acquisition of conditioned place preference in rats

	Irregular morphine administration affects the retention but not acquisition of conditioned place preference in rats
	Meng ZQ 1,3; Liu C 1,3; Hu XT[]1,2; Ma YY[]1,2
刊名	BRAIN RESEARCH
	2010
卷号	1311 期号:X 页码:86-92
关键词	Associative learning Pairing pattern Regularity Retention
ISSN号	0006-8993
通讯作者	xthu@mail.kiz.ac.cn ; yuanma0716@vip.sina.com
英文摘要	Drug addiction is increasingly viewed as the expression of abnormal associative learning following repeated exposures to the drugs of abuse Previous I studies have demonstrated that the patterns of repetition such as frequency and spacing are important to many kinds of learning and memory retention We hypothesized that drug repetition pattern might affect the reward-related learning although the total doses of the drug were the same. In the present study, we tested morphine-induced place preference following either regular or irregular pattern of morphine pairing in rats Regular morphine group received morphine administration daily at a regular time with the same dose Irregular morphine groups received morphine administration either at the same time but irregular doses, irregular time but same dose, or irregular time and irregular doses. We found that rats, who received irregular morphine pairing, exhibited similar acquisition of peace preference but different preference retentions compared with regular morphine-treated rats after the same total dose of morphine Rats, who received morphine administration at the same time but irregular doses and at irregular time and irregular doses, showed rapid disruption of place preference than the regular morphine group. Rats, who received morphine at irregular time but the same dose, showed similar retention of place preference to regular morphine group Our results suggest that the pattern of drug pairing plays an important role in the retention of reward-related memory This study may provide new evidence to broaden our understanding of the development and maintenance of drug craving (C) 2009 Elsevier B V. All rights reserved
学科主题	Neurosciences
收录类别	SCI
资助信息	This study was supported by National Science Foundation of China (NSFC 30530270, 30670669, 30770700, 30870825); Program of CAS (KSCX2-YW-R261); West Light Foundation of the Chinese Academy of Sciences.
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5505]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_神经系统编码
作者单位	1.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China 2.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, PR China 3.Graduate University of the Chinese Academy of Sciences, Beijing 100049, PR China
推荐引用方式 GB/T 7714	Meng ZQ,Liu C,Hu XT[*],et al. Irregular morphine administration affects the retention but not acquisition of conditioned place preference in rats[J]. BRAIN RESEARCH,2010,1311(X):86-92.
APA	Meng ZQ,Liu C,Hu XT[],&Ma YY[].(2010).Irregular morphine administration affects the retention but not acquisition of conditioned place preference in rats.BRAIN RESEARCH,1311(X),86-92.
MLA	Meng ZQ,et al."Irregular morphine administration affects the retention but not acquisition of conditioned place preference in rats".BRAIN RESEARCH 1311.X(2010):86-92.