Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution H-1 NMR spectroscopy

	Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution H-1 NMR spectroscopy
	Gao HC 1,2; Xiang Y 1,2,4; Sun NL 2,3; Zhu H 1,2; Wang YQ 1,2; Liu ML 1; Ma YY[]3; Lei H[]1
刊名	NEUROCHEMISTRY INTERNATIONAL
	2007
卷号	50 期号:2 页码:386-394
关键词	morphine H-1 NMR rat drug dependence metabolism neurotransmitter
ISSN号	0197-0186
通讯作者	yuanma0716@vip.sina.com
合作状况	其它
英文摘要	Ex vivo H-1 NMR spectroscopy was used to measure changes in the concentrations of cerebral metabolites in the prefrontal cortex (PFC) and hippocampus of rats subjected to repeated morphine treatment known to cause tolerance/dependence. The results show that repeated morphine exposure induces significant changes in the concentrations of a number of cerebral metabolites, and such changes are region specific. After 10 days of repeated morphine treatment, the concentration of gamma-aminobutyric acid (GABA) increased significantly in the PFC (20 +/- 11%), but decreased in the hippocampus (-31 +/- 12%), compared to control. In contrast, the glutamate (Glu) concentrations in both the PFC (-15 +/- 8%) and hippocampus (-13 +/- 4%) decreased significantly. Significant changes were also observed in the concentrations of hippocampal glutamine (Gin), myo-inositol, taurine, and N-acetyl aspartate. These morphine-induced changes were reversed during a subsequent 5-day withdrawal period. It is suggested that the observed concentration changes for Glu, Gin and GABA are most likely the result of a shift in the steady-state equilibrium of the Gln-Glu-GABA metabolic cycle. Changes in the metabolism of this neurotransmitter system might be part of the adaptive measures taken by the central nervous system in response to repeated morphine exposure and subsequent withdrawal.
收录类别	SCI
资助信息	This work was supported by grants10234070,30370419and 30400136 from National Natural Science Foundation of China.
原文出处	200750386.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5461]
专题	昆明动物研究所_认知障碍病理学
作者单位	1.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China 2.Graduate School, Chinese Academy of Sciences, Beijing 100049, PR China 3.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 4.Medicine and Life Science School, Jianghan University, Wuhan 430056, PR China
推荐引用方式 GB/T 7714	Gao HC,Xiang Y,Sun NL,et al. Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution H-1 NMR spectroscopy[J]. NEUROCHEMISTRY INTERNATIONAL,2007,50(2):386-394.
APA	Gao HC.,Xiang Y.,Sun NL.,Zhu H.,Wang YQ.,...&Lei H[*].(2007).Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution H-1 NMR spectroscopy.NEUROCHEMISTRY INTERNATIONAL,50(2),386-394.
MLA	Gao HC,et al."Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution H-1 NMR spectroscopy".NEUROCHEMISTRY INTERNATIONAL 50.2(2007):386-394.