Diversified pattern of the human colorectal cancer microbiome

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 进化与功能基因组学

	Diversified pattern of the human colorectal cancer microbiome
	Geng JW 1,2; Fan H 1; Tang XD 1; Zhai HQ 1; Zhang ZG[*]2
刊名	GUT PATHOGENS
	2013
卷号	5 期号:X 页码:e2
关键词	Chinese CRC Microbiome Pyrosequencing
通讯作者	zhangzhigang@mail.kiz.ac.cn
合作状况	其它
英文摘要	Background: The aim of this study is to expand existing knowledge about the CRC-associated microbiome among Han Chinese, and to further discover the variation pattern of the human CRC microbiome across all population. Findings: Using pyrosequencing-based molecular monitoring of bacterial 16S rRNA gene from eight tumor/normal tissue pairs of eight Chinese CRC patients, we analyzed and characterized the basic features of the CRC-associated microbiome. Firstly, we discovered an increasing diversity among tumor-associated bacterial communities. Secondly, in 50% of Chinese CRC patients, we found a significant increase of Roseburia (P = 0.017), and a concurrent decrease of both Microbacterium (P = 0.009) and Anoxybacillus (P = 0.009) in tumor tissue. Conclusions: We discovered a novel CRC microbiome pattern in Chinese. Both the over-represented Roseburia bacteria at tumor sites and the over-represented Microbacterium and Anoxybacillus bacteria away from tumor sites were both closely related in Chinese CRC patients. Across several populations reported in this study and previously, we observed both common and distinctive patterns of human CRC microbiome's association with a high-risk of CRC.
收录类别	SCI
资助信息	This research was supported by grants from Natural Science Foundation of Yunnan Province of China (Grant No. 2010CD191 and Grant No. 2011FA035) and from National Natural Science Foundation of China (NSFC) (Grant No. 31100916).
语种	英语
WOS记录号	WOS:000315940400001
公开日期	2013-04-08
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7289]
专题	昆明动物研究所_进化与功能基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Kunming 650032, China. 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Geng JW,Fan H,Tang XD,et al. Diversified pattern of the human colorectal cancer microbiome[J]. GUT PATHOGENS,2013,5(X):e2.
APA	Geng JW,Fan H,Tang XD,Zhai HQ,&Zhang ZG[*].(2013).Diversified pattern of the human colorectal cancer microbiome.GUT PATHOGENS,5(X),e2.
MLA	Geng JW,et al."Diversified pattern of the human colorectal cancer microbiome".GUT PATHOGENS 5.X(2013):e2.