Reconstruction and analysis of human heart-specific metabolic network based on transcriptome and proteome data

	Reconstruction and analysis of human heart-specific metabolic network based on transcriptome and proteome data
	Zhao YQ 1,2; Huang JF[*]1,3
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2011
卷号	415 期号:3 页码:450-454
关键词	Metabolic network Heart-specific model Flux balance analysis Biomarkers for cardiovascular disease Selective drug targets
通讯作者	huangjf@mail.kiz.ac.cn
合作状况	其它
英文摘要	The availability and utility of genome-scale metabolic networks have exploded with modern genome-sequencing capabilities. However, these generic models overlooked actual physiological states of the tissues and included all the reactions implied by the genome annotations. To address this problem, we reconstructed a human heart-specific metabolic network based on transcriptome and proteome data. The resulting model consists of 2803 reactions and 1880 metabolites, which correspond to 1721 active enzymes in human heart. Using the model, we detected 24 epistatic interactions in human heart, which are useful in understanding both the structure and function of cardiovascular systems. In addition, a set of 776 potential biomarkers for cardiovascular disease (CVD) has been successfully explored, whose concentration is predicted to be either elevated or reduced because of 278 possible dysfunctional cardiovascular-associated genes. The model could also be applied in predicting selective drug targets for eight subtypes of CVD. The human heart-specific model provides valuable information for the studies of cardiac activity and development of CVD.
收录类别	SCI
资助信息	This work was supported by the National Basic Research Pro- gram of China (Grant Nos. 2009CB941300 and 2007CB815705), the National Natural Science Foundation of China (Grant No. 30623007) and Chinese Academy of Sciences (Grant No. 2007211311091) for J.F.H.
语种	英语
公开日期	2012-02-09
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6852]
专题	昆明动物研究所_结构生物信息学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32, Eastern Jiaochang Road, Kunming, Yunnan 650223, China 2.Graduate School of Chinese Academy of Sciences, Beijing 100039, China 3.Kunming Institute of Zoology–Chinese University of Hongkong, Joint Research Center for Bio-resources and Human Disease Mechanisms, Kunming, Yunnan 650223, China
推荐引用方式 GB/T 7714	Zhao YQ,Huang JF[*]. Reconstruction and analysis of human heart-specific metabolic network based on transcriptome and proteome data[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,415(3):450-454.
APA	Zhao YQ,&Huang JF[*].(2011).Reconstruction and analysis of human heart-specific metabolic network based on transcriptome and proteome data.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,415(3),450-454.
MLA	Zhao YQ,et al."Reconstruction and analysis of human heart-specific metabolic network based on transcriptome and proteome data".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 415.3(2011):450-454.