Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper

	Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper
	Yin W 1; Wang ZJ 2,3,4,5; Lu BZ 7; Jin LJ 3; Qiu PX 7; Zhang P 3; Wen B 8; Zhu WB 7; Li QY 3,4,6; Huang YJ 7
刊名	NATURE COMMUNICATIONS
	2016
卷号	7 期号:X 页码:e13107
通讯作者	ygm@mail.sysu.edu.cn ; zhouqi1982@zju.edu.cn
英文摘要	Snakes have numerous features distinctive from other tetrapods and a rich history of genome evolution that is still obscure. Here, we report the high-quality genome of the five-pacer viper, Deinagkistrodon acutus, and comparative analyses with other representative snake and lizard genomes. We map the evolutionary trajectories of transposable elements (TEs), developmental genes and sex chromosomes onto the snake phylogeny. TEs exhibit dynamic lineage-specific expansion, and many viper TEs show brain-specific gene expression along with their nearby genes. We detect signatures of adaptive evolution in olfactory, venom and thermal-sensing genes and also functional degeneration of genes associated with vision and hearing. Lineage-specific relaxation of functional constraints on respective Hox and Tbx limb-patterning genes supports fossil evidence for a successive loss of forelimbs then hindlimbs during snake evolution. Finally, we infer that the ZW sex chromosome pair had undergone at least three recombination suppression events in the ancestor of advanced snakes. These results altogether forge a framework for our deep understanding into snakes' history of molecular evolution.
收录类别	SCI
资助信息	This project was supported by the Thousand Young Talents Program funding, and a startup funding of Life Science Institute of Zhejiang University to Q.Z., and National Major Scientific and Technological Special Project for ‘Significant New Drugs Development’ during the Twelfth Five-year Plan Period (no. 2009ZX09102-217, 2009–2010) to W.Y.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10523]
专题	昆明动物研究所_基因起源组昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510089, China 2.Life Sciences Institute, The Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, Zhejiang University, Hangzhou 310058, China. 3.China National Genebank, BGI-Shenzhen, Shenzhen 518083, China 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 5.School of Bioscience &Bioengineering, South China University of Technology, Guangzhou 510006, China 6.Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, Copenhagen K 1350, Denmark 7.Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510089, China 8.BGI-Shenzhen, Shenzhen 518083, China 9.Centre for Social Evolution, Department of Biology, University of Copenhagen, Universitetsparken 15, Copenhagen DK-2100, Denmark 10.James D. Watson Institute of Genome Sciences, Hangzhou 310058, China.
推荐引用方式 GB/T 7714	Yin W,Wang ZJ,Lu BZ,et al. Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper[J]. NATURE COMMUNICATIONS,2016,7(X):e13107.
APA	Yin W.,Wang ZJ.,Lu BZ.,Jin LJ.,Qiu PX.,...&Zhou Y.(2016).Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper.NATURE COMMUNICATIONS,7(X),e13107.
MLA	Yin W,et al."Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper".NATURE COMMUNICATIONS 7.X(2016):e13107.