Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates

	Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates
	Chen M 1,4; Zou M 1,4; Fu BD 1,4; Li X 2; Vibranovski MD 3; Gan XN 1,4; Wang DQ 1,4,5; Wang W 2; Long MY[]3; He SP[]1
刊名	PLOS ONE
	2011
卷号	6 期号:7 页码:e21466
通讯作者	mlong@uchicago.edu ; clad@ihb.ac.cn
合作状况	其它
英文摘要	The role of RNA-based duplication, or retroposition, in the evolution of new gene functions in mammals, plants, and Drosophila has been widely reported. However, little is known about RNA-based duplication in non-mammalian chordates. In this study, we screened ten non-mammalian chordate genomes for retrocopies and investigated their evolutionary patterns. We identified numerous retrocopies in these species. Examination of the age distribution of these retrocopies revealed no burst of young retrocopies in ancient chordate species. Upon comparing these non-mammalian chordate species to the mammalian species, we observed that a larger fraction of the non-mammalian retrocopies was under strong evolutionary constraints than mammalian retrocopies are, as evidenced by signals of purifying selection and expression profiles. For the Western clawed frog, Medaka, and Sea squirt, many retrogenes have evolved gonad and brain expression patterns, similar to what was observed in human. Testing of retrogene movement in the Medaka genome, where the nascent sex chrosomes have been well assembled, did not reveal any significant gene movement. Taken together, our analyses demonstrate that RNA-based duplication generates many functional genes and can make a significant contribution to the evolution of non-mammalian genomes.
收录类别	SCI
资助信息	This work was supported by grants from National Natural Science Foundation of China [2007CB411601] (http://www.nsfc.gov.cn/Portal0/default124. htm).
语种	英语
公开日期	2011-08-12
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6648]
专题	昆明动物研究所_基因起源组
作者单位	1.Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, People’s Republic of China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, People’s Republic of China 3.Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America 4.Graduate University of Chinese Academy of Sciences, Beijing, People’s Republic of China 5.Yangtze River Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Wuhan, People’s Republic of China
推荐引用方式 GB/T 7714	Chen M,Zou M,Fu BD,et al. Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates[J]. PLOS ONE,2011,6(7):e21466.
APA	Chen M.,Zou M.,Fu BD.,Li X.,Vibranovski MD.,...&He SP[*].(2011).Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates.PLOS ONE,6(7),e21466.
MLA	Chen M,et al."Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates".PLOS ONE 6.7(2011):e21466.