A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China
	Gong XH[]1; Liu YY 1,2; Liu FL 3; Jin L 1; Wang HY 1; Zheng YT[]3
刊名	INFECTION GENETICS AND EVOLUTION
	2015
卷号	34 期号:X 页码:137-142
关键词	HIV-1 Genetic variants SDF1 CCR5 CXCR4 Intravenous drug user
通讯作者	gongxh@fudan.edu.cn ; zhengyt@mail.kiz.ac.cn
合作状况	其它
英文摘要	Despite repeated exposures to HIV-1, some individuals remain uninfected, suggesting that genetic factors confer host resistance to HIV-1 acquisition. The chemokine receptors CCR5, CXCR4 and the principal ligand SDF1 of CXCR4 play an important role for the entry of HIV-1 to target cells. To explore the relationship between genetic variants and HIV-1 infection, 11 common SNPs in CCR5, CXCR4 and SDF1 were genotyped in 921 male intravenous drug users (IDUs), of which 263 individuals were HIV-1-exposed seropositive (HESP) and 658 were HIV-1-exposed seronegative (HESN). According to the situation of syringe-sharing, the whole cohort was divided into two subgroups: syringe-sharing (SS) and syringe-not-sharing (SNS). We found that in the SNS subgroup rs17540465 of SDF1 showed significant difference of allele and genotype frequencies between HESP IDUs and HESN IDUs, but not in the SS subgroup. HESP with SNS carried significantly less allele A compared with HESN with SNS, indicating a protective role of allele A against HIV-1 infection. Syringe-sharing IDUs are supposed to be exposed highly to HIV-1 infection risk due to the direct transfer of HIV-1 infected blood to another. For syringe-not-sharing IDUs, sexual contact may be the major route of HIV-1 transmission. Considering the different route of HIV-1 transfection between two subgroups, we speculate that SDF1 may contribute susceptibility to HIV-1 infection in the route of sexual intercourse.
收录类别	SCI
资助信息	This work was supported by National Basic Research Program of China (2009CB522007), National Natural Science Foundation of China (81271892; U1302224), Natural Science Foundation of Shanghai Municipality (13ZR1402100) and Natural Science Foundation of Anhui Province (1408085QC60).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9411]
专题	昆明动物研究所_分子免疫药理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.The State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Road Songhu 1045, Shanghai, China 2.The Teaching and Research Section of Biochemistry and Molecular Biology, Institute of Chinese and Western Medicine Combined with Clinical, Anhui University of Chinese Medicine, Anhui, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Gong XH[*],Liu YY,Liu FL,et al. A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China[J]. INFECTION GENETICS AND EVOLUTION,2015,34(X):137-142.
APA	Gong XH[],Liu YY,Liu FL,Jin L,Wang HY,&Zheng YT[].(2015).A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China.INFECTION GENETICS AND EVOLUTION,34(X),137-142.
MLA	Gong XH[*],et al."A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China".INFECTION GENETICS AND EVOLUTION 34.X(2015):137-142.