Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 分子免疫药理学

	Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.
	Huang SZ 1,4; Zhang XJ 3,4; Li XY 3,4; Kong LM 1,4; Jiang HZ 1,4; Ma QY 2; Liu YQ 1; Hu, JM 1; Zheng YT 3; Li Y[1]1
刊名	PHYTOCHEMISTRY
	2012
卷号	75 期号:X 页码:99-107
关键词	Daphne acutiloba Thymelaeaceae Daphnane Diterpene ester Cytotoxicity Anti-HIV-1
通讯作者	jzhou@mail.kib.ac.cn ; zhaoyx1011@163.com
合作状况	其它
英文摘要	Seven previously unreported daphnane-type diterpene esters named acutilobins A-G, together with 12 known ones, were isolated from EtOAc extract of Daphne acutiloba Rehd. Their structures were elucidated based on the spectroscopic data. The cytotoxic and anti-HIV-1 activities of these daphnane-type diterpene esters were evaluated through bioassays. Fourteen of these isolates exhibited definite cytotoxic activities against the five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. Additionally, anti-HIV-1 activities were observed in.13 daphnane-type diterpene esters, among which acutilobins A-G exhibited significant anti-HIV-1 activities with EC50 below 1.5 nM and SI over 10,000. Particularly, genkwanineVIII showed the strongest activity with EC50 0.17 nM and SI 187,010.
收录类别	SCI
资助信息	This work was financially supported by National Nonprofit Institute Research Grant of CATAS-ITBB (No. 110301) and Natural Science Foundation of Yunnan (2008CD159).
语种	英语
WOS记录号	WOS:000300868600011
公开日期	2012-09-13
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7089]
专题	昆明动物研究所_分子免疫药理学
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 2.Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, People’s Republic of China 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100049, People’s Republic of China
推荐引用方式 GB/T 7714	Huang SZ,Zhang XJ,Li XY,et al. Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.[J]. PHYTOCHEMISTRY,2012,75(X):99-107.
APA	Huang SZ.,Zhang XJ.,Li XY.,Kong LM.,Jiang HZ.,...&Zhao YX[*].(2012).Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd..PHYTOCHEMISTRY,75(X),99-107.
MLA	Huang SZ,et al."Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.".PHYTOCHEMISTRY 75.X(2012):99-107.