Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China

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	Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China
	Yang RG 1; Kusagawa S 1; Zhang CY 2; Xia XS 2; Ben KL 2; Takebe Y[*]1
刊名	JOURNAL OF VIROLOGY
	2003
卷号	77 期号:1 页码:685-695
ISSN号	0022-538X
通讯作者	takebe@nih.go.jp
合作状况	其它
英文摘要	We identified a new class of human immunodeficiency virus type 1 (HIV-1) recombinants (00CN-HH069 and 00CN-HH086) in which further recombination occurred between two established circulating recombinant forms (CRFs). These two isolates were found among 57 HIV-1 samples from a cohort of injecting drug users in eastern Yunnan Province of China. Informative-site analysis in conjunction with bootscanning plots and exploratory tree analysis revealed that these two strains were closely related mosaics comprised of CRF07_BC and CRF08_BC, which are found in China. The genotype screening based on gag-reverse transcriptase sequences if 57 samples from eastern Yunnan identified 47 CRF08_BC specimens (82.5%), 5 CRF07_BC specimens (8.8%), and 3 additional specimens with the novel recombinant structure. These new "second-generation" recombinants thus constitute a substantial proportion (5 of 57; 8.8%) of HIV-1 strains in this population and may belong to a new but yet-undefined class of CRF. This might be the first example of CRFs recombining with each other, leading to the evolution of second-generation inter-CRF recombinants.
收录类别	SCI
资助信息	This study was supported by a grant-in-aid for AIDS research from the Ministry of Health, Labour and Welfare and the Ministry of Ed- ucation, Science and Technology of Japan and by the Japanese Foun- dation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowships from JFAP.
原文出处	200377685.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5289]
专题	昆明动物研究所_其他
作者单位	1.Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China
推荐引用方式 GB/T 7714	Yang RG,Kusagawa S,Zhang CY,et al. Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China[J]. JOURNAL OF VIROLOGY,2003,77(1):685-695.
APA	Yang RG,Kusagawa S,Zhang CY,Xia XS,Ben KL,&Takebe Y[*].(2003).Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China.JOURNAL OF VIROLOGY,77(1),685-695.
MLA	Yang RG,et al."Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China".JOURNAL OF VIROLOGY 77.1(2003):685-695.