Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.
	Strakova A 1; Ní Leathlobhair M 1; Allen JL 4; Allum KM 5; Bansse-Issa L 6; Bisson JL 1; Castillo Domracheva A 7; Wang GD 2; Yin TT 2; Airikkala-Otter I 3
刊名	ELIFE
	2016
卷号	5 期号:X 页码:e14552
关键词	Dog mitochondria cancer biology transmissible cancer canine transmissible venereal tumour evolutionary biology genomics
通讯作者	epm27@cam.ac.uk
英文摘要	Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.
收录类别	SCI
资助信息	This work was supported by grants from the Wellcome Trust (102942/Z/13/A) and the Royal Society (RG130615), and a Philip Leverhulme Prize from the Leverhulme Trust. We are grateful to Michael Stratton for his support.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9875]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom. 2.State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.International Training Center, Worldwide Veterinary Service, Aruvankadu, India. 4.Animal Management in Rural and Remote Indigenous Communities, Darwin, Australia 5.World Vets, Fargo, United States 6.Stichting Dierenbescherming Suriname, Paramaribo, Suriname 7.Corozal Veterinary Hospital, University of Panama, Panama City, Panama. 8.Department of Clinical and Veterinary Surgery, São Paulo State University, São Paulo, Brazil 9.St. George's University, True Blue, Grenada 10.The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.
推荐引用方式 GB/T 7714	Strakova A,Ní Leathlobhair M,Allen JL,et al. Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.[J]. ELIFE,2016,5(X):e14552.
APA	Strakova A.,Ní Leathlobhair M.,Allen JL.,Allum KM.,Bansse-Issa L.,...&Murchison EP[*].(2016).Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer..ELIFE,5(X),e14552.
MLA	Strakova A,et al."Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.".ELIFE 5.X(2016):e14552.