Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: A meta-analysis

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	Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: A meta-analysis
	Jiang HY 1,2; Qiao F 3; Li ZF 4; Zhang YP 1,5; Cheng YQ 2; Xu XF[]2; Yu L[]1
刊名	ASIA-PACIFIC PSYCHIATRY
	2015
卷号	7 期号:3 页码:260-267
关键词	CACNA1C East Asian European rs1006737 schizophrenia
通讯作者	xfxu2004@sina.com ; yuli-1220@163.com
合作状况	其它
英文摘要	Introduction: Genetic analyses including genome-wide association studies have reported an intronic single nucleotide polymorphism (SNP) rs1006737 in CACNA1C gene (encoded calcium channel, voltage-dependent, L type, alpha 1C subunit) as a risk factor for schizophrenia in European populations. The replications in other ethnic populations such as East Asians have also been conducted, but the results were inconsistent, either likely due to the limited sample size of single study or genetic heterogeneity between continental populations on this locus. Methods: We performed a comprehensive meta-analysis of all available samples from existing studies of East Asian populations, including a total of 9,432 cases and 10,661 controls, to further confirm whether CACNA1C rs1006737 is an authentic risk SNP for schizophrenia in East Asian populations. Results: Our results revealed a significant association between rs1006737 and schizophrenia (allelic model, P = 4.39 x 10(-6), pooled odds ratio [OR] = 1.20), and the results were much strengthened when the European and East Asian samples were combined together (P = 2.40 x 10(-17), pooled OR = 1.12). There is no significant heterogeneity or publication bias between individual studies, and removal of any single study still remained significant associations between rs1006737 and schizophrenia. Discussion: Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations.
收录类别	SCI
资助信息	This work was supported by a grant from the Foun- dation for the Development of Key Departments of Kunming Medical University (2011-13142).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9567]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Laboratory for Conservation and Utilization of Bio-resource, Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, Yunnan, China 2.Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 3.Department of Anesthesiology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 4.Department of Radiology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 5.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming,Yunnan, China
推荐引用方式 GB/T 7714	Jiang HY,Qiao F,Li ZF,et al. Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: A meta-analysis[J]. ASIA-PACIFIC PSYCHIATRY,2015,7(3):260-267.
APA	Jiang HY.,Qiao F.,Li ZF.,Zhang YP.,Cheng YQ.,...&Yu L[*].(2015).Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: A meta-analysis.ASIA-PACIFIC PSYCHIATRY,7(3),260-267.
MLA	Jiang HY,et al."Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: A meta-analysis".ASIA-PACIFIC PSYCHIATRY 7.3(2015):260-267.