Draft genome sequence of the Tibetan antelope

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Draft genome sequence of the Tibetan antelope
	Ge RL[]1; Cai QL 2; Shen YY 3,4; San A 2; Ma L 1; Zhang Y 2; Yi X 2; Murphy RW 3,16; Wang J[]2,17,18; Zhang YP[*]3
刊名	NATURE COMMUNICATIONS
	2013
卷号	4 期号:X 页码:1-7;Article1858,
通讯作者	geriligao@hotmail.com ; zhangyp@mail.kiz.ac.cn ; wangjian@genomics.org.cn
合作状况	其它
英文摘要	The Tibetan antelope (Pantholops hodgsonii) is endemic to the extremely inhospitable high-altitude environment of the Qinghai-Tibetan Plateau, a region that has a low partial pressure of oxygen and high ultraviolet radiation. Here we generate a draft genome of this artiodactyl and use it to detect the potential genetic bases of highland adaptation. Compared with other plain-dwelling mammals, the genome of the Tibetan antelope shows signals of adaptive evolution and gene-family expansion in genes associated with energy metabolism and oxygen transmission. Both the highland American pika, and the Tibetan antelope have signals of positive selection for genes involved in DNA repair and the production of ATPase. Genes associated with hypoxia seem to have experienced convergent evolution. Thus, our study suggests that common genetic mechanisms might have been utilized to enable high-altitude adaptation.
收录类别	SCI
资助信息	This work was supported by National Basic Research Program of China (No.2006CB504100, 2007CB411600 and 2012CB518200), Basic Science Research Foun- dation of Bureau of Science and Technology in Qinghai Provinces (2010-1456), Program of International S&T Cooperation of China (No.0S2012GR0195), National Nature Sci- ence Foundation of China (No.30393133), Bureau of Science and Technology of Yunnan Province, Chinese Academy of Sciences and Natural Sciences and Engineering Research Council (Discovery Grant 3148).
语种	英语
WOS记录号	WOS:000320589900054
公开日期	2013-08-08
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7580]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.Key Laboratory for High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University, Xining, Qinghai 810001, China 2.BGI-Shenzhen, Shenzhen 518083, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, China 4.State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China 5.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 6.Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, China 7.Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA 8.Department of Animal Biotechnology, Konkuk University, Seoul 143-701, Korea 9.Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, Ceredigion SY23 3DA, UK 10.Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
推荐引用方式 GB/T 7714	Ge RL[*],Cai QL,Shen YY,et al. Draft genome sequence of the Tibetan antelope[J]. NATURE COMMUNICATIONS,2013,4(X):1-7;Article1858,.
APA	Ge RL[].,Cai QL.,Shen YY.,San A.,Ma L.,...&Zhang YP[].(2013).Draft genome sequence of the Tibetan antelope.NATURE COMMUNICATIONS,4(X),1-7;Article1858,.
MLA	Ge RL[*],et al."Draft genome sequence of the Tibetan antelope".NATURE COMMUNICATIONS 4.X(2013):1-7;Article1858,.