Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus
	Hao DC 1,4; Sun J 2; Furnes B 3; Schlenk D 3; Hou ZF 4,5; Zhang YP 5; Yang SL 1; Yang L[*]1
刊名	BIOCHEMICAL GENETICS
	2006
卷号	44 期号:7-8 页码:391-407
关键词	FMO3 linkage polymorphism evolution haplotype frequency
ISSN号	0006-2928
通讯作者	yling@dicp.ac.cn
英文摘要	We analyzed flavin-containing monooxygenase 3 (FMO3) polymorphisms, haplotype structure, and linkage disequilibrium (LD) in 256 Han Chinese and 50 African-American individuals to compare their haplotype frequencies and LD with other world populations. For the Han Chinese, genotyping of three haplotype tag single nucleotide polymorphisms (E158K, V257M, and E308G) was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism. For the African-Americans, genotyping of all coding exons was performed by modified PCR-single strand conformational polymorphism. Haplotype frequencies, LD, and evolutionary rates were inferred and estimated computationally. There were significant differences in haplotype frequency distribution and LD pattern among Han Chinese, African-Americans, and other world populations. Four major haplotypes of Han Chinese were EVE, KVE, EME, and EVG. Two major haplotypes of African-Americans were EVE and KVE. We found that sites 158 and 257 are in significant LD in both populations. This is the first report comparing FMO haplotypes and LD of Han Chinese with African-Americans. The data presented here justify further pharmacogenetic studies for potentially optimizing recommended drug dosages and evaluating relationships with disease processes.
收录类别	SCI
资助信息	This work is supported by the 973 Program (2003CCA03400) of the Ministry of Science and Technology of China.
原文出处	200644391.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4189]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_细胞与分子进化开放实验室管理、支撑部门_计划财务处
作者单位	1.Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China 2.Department of Emergency Medicine, Dalian Medical University, Dalian, China 3.Environmental Toxicology Program, University of California, Riverside, CA, USA 4.The Graduate School, Chinese Academy of Sciences, Beijing, China 5.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Hao DC,Sun J,Furnes B,et al. Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus[J]. BIOCHEMICAL GENETICS,2006,44(7-8):391-407.
APA	Hao DC.,Sun J.,Furnes B.,Schlenk D.,Hou ZF.,...&Yang L[*].(2006).Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus.BIOCHEMICAL GENETICS,44(7-8),391-407.
MLA	Hao DC,et al."Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus".BIOCHEMICAL GENETICS 44.7-8(2006):391-407.