Adaptive diversification of vomeronasal receptor 1 genes in rodents

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 分子进化基因组学

	Adaptive diversification of vomeronasal receptor 1 genes in rodents
	Shi P 1,2,3; Bielawski JP 4,5; Yang H 1,3; Zhang YP[*]1,2
刊名	JOURNAL OF MOLECULAR EVOLUTION
	2005
卷号	60 期号:5 页码:566-576
关键词	Vomeronasal receptor Positive selection Gene duplication Codon model
ISSN号	0022-2844
通讯作者	zhangyp@public. km.yn.cn or zhangypl@263.net.cn
合作状况	其它
英文摘要	The vomeronasal receptor 1 (V1R) are believed to be pheromone receptors in rodents. Here we used computational methods to identify 95 and 62 new putative V1R genes from the draft rat and mouse genome sequence, respectively. The rat V1R repertoire consists of 11 subfamilies, 10 of which are shared with the mouse, while rat appears to lack the H and I subfamilies found in mouse and possesses one unique subfamily (M). The estimations of the relative divergence times suggest that many subfamilies originated after the split of rodents and primates. The analysis also reveals that these clusters underwent an expansion very close to the split of mouse and rat. In addition, maximum likelihood analysis showed that the nonsynonymous and synonymous rate ratio for most of these clusters was much higher than one, suggesting the role of positive selection in the diversification of these duplicated V1R genes. Because V1R are thought to mediate the process of signal transduction in response to pheromone detection, we speculate that the V1R genes have evolved under positive Darwinian selection to maintain the ability to discriminate between large and complex pheromonal mixtures.
收录类别	SCI
资助信息	This work was supported by grants from the Chinese Academy of Sciences (KSCX2-1-05), the National Natural Science Foundation of China (30430110 and 30021004), and the Program for Key International S & T Cooperation Project of P.R. China (2001CB711103) to Y.P.Z, a startup fund from Dalhousie Unievrsity to J.P.B., and a grant from the Genome Atlantic Centre of Genome Canada to J.P.B.
原文出处	200560566.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4175]
专题	昆明动物研究所_分子进化基因组学昆明动物研究所_进化与功能基因组学昆明动物研究所_细胞与分子进化开放实验室
作者单位	1.Laboratory of Molecular Biology of Domestic Animals and Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China 3.The Graduate School, Chinese Academy of Sciences, Beijing 100039, China 4.Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada 5.Department of Mathematics & Statistics, Dalhousie University, Halifax, Nova Scotia, Canada
推荐引用方式 GB/T 7714	Shi P,Bielawski JP,Yang H,et al. Adaptive diversification of vomeronasal receptor 1 genes in rodents[J]. JOURNAL OF MOLECULAR EVOLUTION,2005,60(5):566-576.
APA	Shi P,Bielawski JP,Yang H,&Zhang YP[*].(2005).Adaptive diversification of vomeronasal receptor 1 genes in rodents.JOURNAL OF MOLECULAR EVOLUTION,60(5),566-576.
MLA	Shi P,et al."Adaptive diversification of vomeronasal receptor 1 genes in rodents".JOURNAL OF MOLECULAR EVOLUTION 60.5(2005):566-576.