Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study
	Li ZZ 1,2; Zhang C 1,3; Fan JB 4; Yuan CM 1; Huang J 1; Chen J 1; Yi ZH 1; Wang ZW 1; Hong W 1; Wang Y 1
刊名	BRITISH JOURNAL OF PSYCHIATRY
	2014
卷号	205 期号:1 页码:29-35
通讯作者	yanyansong@sjtu.edu.cn
合作状况	其它
英文摘要	Background Early identification of patients with bipolar disorder during their first depressive episode is beneficial to the outcome of the disorder and treatment, but traditionally this has been a great challenge to clinicians. Recently, brain-derived neurotrophic factor (BDNF) has been suggested to be involved in the pathophysiology of bipolar disorder and major depressive disorder (MDD), but it is not clear whether BDNF levels can be used to predict bipolar disorder among patients in their first major depressive episode. Aims To explore whether BDNF levels can differentiate between MDD and bipolar disorder in the first depressive episode. Method A total of 203 patients with a first major depressive episode as well as 167 healthy controls were recruited. After 3 years of bi-annual follow-up, 164 patients with a major depressive episode completed the study, and of these, 21 were identified as having bipolar disorder and 143 patients were diagnosed as having MDD. BDNF gene expression and plasma levels at baseline were compared among the bipolar disorder, MDD and healthy control groups. Logistic regression and decision tree methods were applied to determine the best model for predicting bipolar disorder at the first depressive episode. Results At baseline, patients in the bipolar disorder and MDD groups showed lower BDNF mRNA levels (P<0.001 and P=0.02 respectively) and plasma levels (P=0.002 and P=0.01 respectively) compared with healthy controls. Similarly, BDNF levels in the bipolar disorder group were lower than those in the MDD group. These results showed that the best model for predicting bipolar disorder during a first depressive episode was a combination of BDNF mRNA levels with plasma BDNF levels (receiver operating characteristics (ROC)=0.80, logistic regression; ROC=0.84, decision tree). Conclusions Our findings suggest that BDNF levels may serve as a potential differential diagnostic biomarker for bipolar disorder in a patient's first depressive episode.
收录类别	SCI
资助信息	This study was supported by the National Natural Science Foundation of China (91232719, 30971047, 81000581, 81171272), National High-tech R&D Program (863 Program, 2006AA02Z430, Ministry of Science and Technology of China), the ‘‘12th Five-year Plan’’ of National Key Technologies R&D Program (2012BAI01B04, Ministry of Science and Technology of China), National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH, 2011-873), Shanghai Natural Science Foundation (13ZR1460500, 10ZR1426600), Shanghai Health Bureau Project, Shanghai Changhai Hospital Foundation, and Postdoctoral Grant of Secondary Military Medical University.
语种	英语
WOS记录号	WOS:000338978100007
公开日期	2014-07-14
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7956]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_分子病理学
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Div Mood Disorders, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China 2.Secondary Mil Med Univ, Shanghai Changhai Hosp, Dept Neurol, Shanghai, Peoples R China 3.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China 4.Case Western Reserve Univ, Sch Med, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA 5.Secondary Mil Med Univ, Shanghai Changhai Hosp, Dept Neurol, Shanghai, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Dept Genet, Shanghai 200030, Peoples R China 7.Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China 8.Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Dept Pharmacol & Biostat, Shanghai 200030, Peoples R China
推荐引用方式 GB/T 7714	Li ZZ,Zhang C,Fan JB,et al. Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study[J]. BRITISH JOURNAL OF PSYCHIATRY,2014,205(1):29-35.
APA	Li ZZ.,Zhang C.,Fan JB.,Yuan CM.,Huang J.,...&Fang YR[*].(2014).Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study.BRITISH JOURNAL OF PSYCHIATRY,205(1),29-35.
MLA	Li ZZ,et al."Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study".BRITISH JOURNAL OF PSYCHIATRY 205.1(2014):29-35.