Significantly decreased mRNA levels of BDNF and MEK1 genes in treatment-resistant depression

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Significantly decreased mRNA levels of BDNF and MEK1 genes in treatment-resistant depression
	Hong W 1; Fan JB 3; Yuan CM 1; Zhang C 1,2; Hu YY 1; Peng DH 1; Wang Y 1; Huang J 1; Li ZZ 1; Yu SY 1
刊名	NEUROREPORT
	2014
卷号	25 期号:10 页码:753-755
关键词	brain-derived neurotrophin factor mitogen-activated protein kinase kinase 1 treatment-resistant depression treatment-responsive depression
通讯作者	yirufang@gmail.com
合作状况	其它
英文摘要	The aim of the current study was to investigate whether the levels of mRNA expression of brain-derived neurotrophin factor (BDNF) and a related gene MEK1 were more obviously decreased in treatment-resistant depression (TRD). In total, 50 patients with major depressive disorder (including 26 with TRD and 24 with treatment-responsive depression) and 48 healthy controls were enrolled. BDNF and MEK1 mRNA levels in blood samples from all patients and controls were measured using reverse transcriptase-PCR. BDNF and MEK1 mRNA levels were significantly reduced in patients with major depressive disorder when compared with healthy controls (BDNF: P<0.01; MEK1: P<0.001), as well as among treatment-resistant depressive patients as compared with treatment-responsive depressive patients (BDNF: P<0.001; MEK1: P<0.01). Our findings support the hypothesis that BDNF and MEK1 mRNA expression levels are more obviously decreased in patients with TRD.
收录类别	SCI
资助信息	This study was supported by the ‘12th five-year plan’ of National Key Technologies R&D Program (2012BAI01B04), National Natural Science Foundation of China (91232719), National Key Clinical Disciplines at Shanghai Mental Health Center (2011-873), National High-tech R&D Program (863 Program; 2006AA02Z430), the Program of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine (2011-YJ-06), and Program of Health Department of Shanghai Muni- cipal Government(2013-71). Dr Jinbo Fan was supported in part by NIH/NCRR CTSA KL2RR024990.
语种	英语
WOS记录号	WOS:000337728800005
公开日期	2014-06-23
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7914]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_分子病理学
作者单位	1.Shanghai Mental Health Center, Division of Mood Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, China 3.Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
推荐引用方式 GB/T 7714	Hong W,Fan JB,Yuan CM,et al. Significantly decreased mRNA levels of BDNF and MEK1 genes in treatment-resistant depression[J]. NEUROREPORT,2014,25(10):753-755.
APA	Hong W.,Fan JB.,Yuan CM.,Zhang C.,Hu YY.,...&Fang YR[*].(2014).Significantly decreased mRNA levels of BDNF and MEK1 genes in treatment-resistant depression.NEUROREPORT,25(10),753-755.
MLA	Hong W,et al."Significantly decreased mRNA levels of BDNF and MEK1 genes in treatment-resistant depression".NEUROREPORT 25.10(2014):753-755.