Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning

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	Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning
	Ma PC 1,4; Zhao SH 2; Zeng WL 1,4; Yang QT 3; Li CC 1; Lv XY 3; Zhou Q 3; Mao BY[*]1
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2011
卷号	412 期号:1 页码:170-174
关键词	Dbx1 Dbx2 Xenopus Neurogenesis Neural plate patterning
通讯作者	mao@mail.kiz.ac.cn
合作状况	其它
英文摘要	The evolutionarily conserved Dbx homeodomain-containing proteins play important roles in the development of vertebrate central nervous system. In mouse, Dbx and Nkx6 have been suggested to be cross-repressive partners involved in the patterning of ventral neural tube. Here, we have isolated Xenopus Dbx2 and studied its developmental expression and function during neural development. Like XDbx1, from mid-neurula stage on, XDbx2 is expressed in stripes between the primary motoneurons and interneurons. At the tailbud stages, it is detected in the middle region of the neural tube. XDbx2 acts as a transcriptional repressor in vitro and over-expression of XDbx2 inhibits primary neurogenesis in Xeno pus embryos. Over-expression of XDbx genes represses the expression of XNkx6.2 and vise versa. Knockdown of either XDbx1, XDbx2 or both by specific morpholinos induces lateral expansion of XNkx6.2 expression domains. These data reveal conserved roles for Dbx in primary neurogenesis and dorsoventral neural patterning in Xenopus.
收录类别	SCI
资助信息	This work was supported by grants from the Key State Research Program from the Ministry of Science and Technology of China (2007CB947201) and the State Key Laboratory of Genetic Resources and Evolution.
语种	英语
公开日期	2011-09-19
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6785]
专题	昆明动物研究所_发育生物学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Yunnan Key Laboratory of Fertility Regulation and Minority Eugenics, Yunnan Population and Family Planning Research Institute, Kunming 650021, China 3.The Core Facility of Genetically Engineered Mice, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China 4.Graduate University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式 GB/T 7714	Ma PC,Zhao SH,Zeng WL,et al. Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,412(1):170-174.
APA	Ma PC.,Zhao SH.,Zeng WL.,Yang QT.,Li CC.,...&Mao BY[*].(2011).Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,412(1),170-174.
MLA	Ma PC,et al."Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 412.1(2011):170-174.