Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 动物活性蛋白多肽组学

	Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians
	Yang XW 1,3; Wang Y 2; Zhang Y 1; Lee WH 1; Zhang Y[*]1
刊名	SCIENTIFIC REPORTS
	2016
卷号	6 期号:X 页码:e19866.
通讯作者	zhangy@mail.kiz.ac.cn
英文摘要	Elucidating the mechanisms of high-altitude adaptation is an important research area in modern biology. To date, however, knowledge has been limited to the genetic mechanisms of adaptation to the lower oxygen and temperature levels prevalent at high altitudes, with adaptation to UV radiation largely neglected. Furthermore, few proteomic or peptidomic analyses of these factors have been performed. In this study, the molecular adaptation of high-altitude Odorrana andersonii and cavernicolous O. wuchuanensis to elevated UV radiation was investigated. Compared with O. wuchuanensis, O. andersonii exhibited greater diversity and free radical scavenging potentiality of skin antioxidant peptides to cope with UV radiation. This implied that O. andersoniievolved a much more complicated and powerful skin antioxidant peptide system to survive high-altitude UV levels. Our results provided valuable peptidomic clues for understanding the novel molecular basis for adaptation to high elevation habitats.
收录类别	SCI
资助信息	This work was supported by grants from the Chinese National Natural Science Foundation (U1132601, 31270835, 31572268 and 31460571) and the Key Research Program of the Chinese Academy of Sciences (KJZD-EW-L03).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9538]
专题	昆明动物研究所_动物活性蛋白多肽组学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Key Laboratory of Chemistry in Ethnic Medicine Resource, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming 650500, China 3.Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China
推荐引用方式 GB/T 7714	Yang XW,Wang Y,Zhang Y,et al. Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians[J]. SCIENTIFIC REPORTS,2016,6(X):e19866..
APA	Yang XW,Wang Y,Zhang Y,Lee WH,&Zhang Y[*].(2016).Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians.SCIENTIFIC REPORTS,6(X),e19866..
MLA	Yang XW,et al."Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians".SCIENTIFIC REPORTS 6.X(2016):e19866..