Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5.

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 动物毒素室

	Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5.
	Wang G 1,2; Rong MQ 2; Li Q 3; Liu YP 3; Long CB 2; Meng P 2; Yao HM 1; Lai R[]1,2; Luo XD[]3
刊名	TOXINS
	2016
卷号	8 期号:1 页码:e12
关键词	NaV1.5 Veratrum taliense cardiovascular toxicity
通讯作者	rlai@mail.kiz.ac.cn
合作状况	其它
英文摘要	Several species of the genus Veratrum that produce steroid alkaloids are commonly used to treat pain and hypertension in China and Europe. However, Veratrum alkaloids (VAs) induce serious cardiovascular toxicity. In China, Veratrum treatment often leads to many side effects and even causes the death of patients, but the pathophysiological mechanisms under these adverse effects are not clear. Here, two solanidine-type VAs (isorubijervine and rubijervine) isolated from Veratrum taliense exhibited strong cardiovascular toxicity. A pathophysiological study indicated that these VAs blocked sodium channels Na(V)1.3-1.5 and exhibited the strongest ability to inhibit Na(V)1.5, which is specifically expressed in cardiac tissue and plays an essential role in cardiac physiological function. This result reveals that VAs exert their cardiovascular toxicity via the Na(V)1.5 channel. The effects of VAs on Na(V)1.3 and Na(V)1.4 may be related to their analgesic effect and skeletal muscle toxicity, respectively.
收录类别	SCI
资助信息	This work was supported by the Ministry of Science and Technology of China(2013CB911300), NSFC (31260208, U1132601, 31200590, 81573320 and 81225024).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9519]
专题	昆明动物研究所_动物毒素室昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 3.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China
推荐引用方式 GB/T 7714	Wang G,Rong MQ,Li Q,et al. Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5.[J]. TOXINS,2016,8(1):e12.
APA	Wang G.,Rong MQ.,Li Q.,Liu YP.,Long CB.,...&Luo XD[*].(2016).Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5..TOXINS,8(1),e12.
MLA	Wang G,et al."Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5.".TOXINS 8.1(2016):e12.