Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration

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	Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration
	Wen ZY 1,2; Yan ZQ 1; Hu KL 3; Pang ZQ 1; Cheng XF 1; Guo LR 1; Zhang QZ 1; Jiang XG[]1; Fang L[]2; Lai R[*]4
刊名	JOURNAL OF CONTROLLED RELEASE
	2011
卷号	151 期号:2 页码:131-138
关键词	Odorranalectin Nose-to-brain delivery Parkinson's disease Urocortin peptide Nanoparticles
通讯作者	xgjiang@shmu.edu.cn ; fangliang2003@yahoo.com ; rlai@mail.kiz.ac.cn
合作状况	其它
英文摘要	Odorranalectin (OL) was recently identified as the smallest lectin with much less immunogenicity than other members of the lectin family. In this study, to improve nose-to-brain drug delivery and reduce the immunogenicity of traditional lectin modified delivery system, OL was conjugated to poly(ethylene glycol)poly( lactic-co-glycolic acid) (PEG-PLGA) nanoparticles and its biorecognitive activity on nanoparticles was verified by haemagglutination tests. Nose-to-brain delivery characteristic of OL-conjugated nanoparticles (OL-NP) was investigated by in vivo fluorescence imaging technique using DiR as a tracer. Besides, urocortin peptide (UCN), as a macromolecular model drug, was incorporated into nanoparticles and evaluated for its therapeutic efficacy on hemiparkinsonian rats following intranasal administration by rotation behavior test, neurotransmitter determination and tyrosine hydroxylase (TH) test. The results suggested that OL modification increased the brain delivery of nanoparticles and enhanced the therapeutic effects of UCN-loaded nanoparticles on Parkinson's disease. In summary, the OL-NPs could be potentially used as carriers for nose-to-brain drug delivery, especially for macromolecular drugs, in the treatment of CNS disorders.
收录类别	SCI
资助信息	This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657)
语种	英语
公开日期	2014-06-18
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7908]
专题	昆明动物研究所_动物毒素室昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Department of Pharmaceutical Science, School of Pharmacy, Fudan University, Shanghai 201203, China 2.Department of Pharmaceutical Science, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning110016, China 3.Murad Research Center for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China 4.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan, China
推荐引用方式 GB/T 7714	Wen ZY,Yan ZQ,Hu KL,et al. Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration[J]. JOURNAL OF CONTROLLED RELEASE,2011,151(2):131-138.
APA	Wen ZY.,Yan ZQ.,Hu KL.,Pang ZQ.,Cheng XF.,...&Lai R[*].(2011).Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration.JOURNAL OF CONTROLLED RELEASE,151(2),131-138.
MLA	Wen ZY,et al."Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration".JOURNAL OF CONTROLLED RELEASE 151.2(2011):131-138.