A novel frog skin peptide containing function to induce muscle relaxation

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 动物毒素室

	A novel frog skin peptide containing function to induce muscle relaxation
	Meng P 1; Wei L 1; Yang SL 2; Liu H 2; Liu R[]2; Lai R[]1,2
刊名	BIOCHIMIE
	2012
卷号	94 期号:12 页码:2508-2513
关键词	Amphibian Skin Myotropic peptide Polypedates pingbianensis Tree frog
通讯作者	liurui@mail.kiz.ac.cn ; rlai72@njau.edu.cn
合作状况	其它
英文摘要	A novel bioactive peptide (polypedarelaxin 1) was identified from the skin secretions of the tree frog, Polypedates pingbianensis. Polypedarelaxin 1 is composed of 21 amino acid residues with a sequence of QGGLLGKVSNLANDALGILPI. Its primary structure was further confirmed by cDNA cloning and mass spectrometry analysis. Polypedarelaxin 1 was found to elicit concentration-dependent relaxation effects on isolated rat ileum. It has no antimicrobial and serine protease inhibitory activities. BLAST search revealed that polypedarelaxin 1 did not show similarity to known proteins or peptides. Especially, polypedarelaxin 1 do not contain conserved structural motifs of other amphibian myotropic peptides, such as bradykinins, bombesins, cholecystokinin (CCK), and tachykinins, indicating that polypedarelaxin 1 belongs to a novel family of amphibian myotropic peptide. (C) 2012 Elsevier Masson SAS.
收录类别	SCI
资助信息	This work was supported by Chinese National Natural Science Foundation (30830021, 31025025, 31070701, 31000960, U1132601), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091, 2011ZX09102-002-10), the Ministry of Agriculture (2009ZX08009-159B) and Yunnan Province (Y103951111).
语种	英语
WOS记录号	WOS:000312517800007
公开日期	2013-09-17
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7640]
专题	昆明动物研究所_动物毒素室昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Life Sciences College of Nanjing Agricultural University, 1st Weigang, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunan Provinces, Kunming Institute of Zoology, Kunming 650223, Yunnan, China
推荐引用方式 GB/T 7714	Meng P,Wei L,Yang SL,et al. A novel frog skin peptide containing function to induce muscle relaxation[J]. BIOCHIMIE,2012,94(12):2508-2513.
APA	Meng P,Wei L,Yang SL,Liu H,Liu R[],&Lai R[].(2012).A novel frog skin peptide containing function to induce muscle relaxation.BIOCHIMIE,94(12),2508-2513.
MLA	Meng P,et al."A novel frog skin peptide containing function to induce muscle relaxation".BIOCHIMIE 94.12(2012):2508-2513.