Recombinant Human Gonadotropins for Rhesus Monkey Superovulation: Age and the Stimulation Interval are Determinant to the Fecundity

	Recombinant Human Gonadotropins for Rhesus Monkey Superovulation: Age and the Stimulation Interval are Determinant to the Fecundity
	Chen YC 1,2,3,4; Ji SH 1,2,3; Niu YY 1,2,3; He XC 1,2,3; Xie YH 1; Tang XH 1,2; Ji WZ[*]1,2,3
刊名	JOURNAL OF ANIMAL AND VETERINARY ADVANCES
	2012
卷号	10 期号:24 页码:3303-3307
关键词	uperovulation recombinant human gonadotropins age
合作状况	其它
英文摘要	The objective of this study was to analysis the key factors which may be determinative to Superovulation (SO) in rhesus monkey. Total 361 rhesus monkeys were stimulated with recombinant human gonadotropins and Ova Pick Up (OPU) was conducted by laparoscopic follicular aspiration. Number of total ova and oocytes at Metaphase I (MI) and Metaphase II (MII) (MI+MII) from each retrieval was calculated, MI+MII >= 10 was defined as effective SO-OPU while MI+MII<10 was defined as non-effective SO-OPU. Parameters including age, month in breeding season, stimulated times and stimulation interval were compared between effective and non-effective SO-OPU. The results showed that 5-10 years old rhesus monkeys were ideal oocytes donors while 3-4 years old and >10 years old monkeys included high rate of poor responders. SO conducted from late October to next February harvested similar fecundity while the rate of poor responders increased in March which imply proper SO breeding season should be from late October to next February. In addition, SO-OPU outcomes were gradually decreased along with the increased times of repeated stimulation. Further analysis showed that stimulation interval affected monkeys' response to recombinant ant human gonadotropins. When the interval was <2 menstrual cycles, the fecundity compromised significantly. In conclusion, the key determinative factors to SO-OPU should be animal's age and stimulation interval in rhesus monkey stimulated with recombinant human gonadotropins
收录类别	SCI
语种	英语
公开日期	2012-04-05
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/6907]
专题	昆明动物研究所_生殖与发育生物学昆明动物研究所_哺乳动物胚胎发育
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, Dept Reprod & Dev Biol, Kunming 650223, Peoples R China 2.Yunnan Key Lab Anim Reprod Biol, Kunming 650223, Peoples R China 3.Ctr Biomed & Anim Sci, Kunming 650051, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Chen YC,Ji SH,Niu YY,et al. Recombinant Human Gonadotropins for Rhesus Monkey Superovulation: Age and the Stimulation Interval are Determinant to the Fecundity[J]. JOURNAL OF ANIMAL AND VETERINARY ADVANCES,2012,10(24):3303-3307.
APA	Chen YC.,Ji SH.,Niu YY.,He XC.,Xie YH.,...&Ji WZ[*].(2012).Recombinant Human Gonadotropins for Rhesus Monkey Superovulation: Age and the Stimulation Interval are Determinant to the Fecundity.JOURNAL OF ANIMAL AND VETERINARY ADVANCES,10(24),3303-3307.
MLA	Chen YC,et al."Recombinant Human Gonadotropins for Rhesus Monkey Superovulation: Age and the Stimulation Interval are Determinant to the Fecundity".JOURNAL OF ANIMAL AND VETERINARY ADVANCES 10.24(2012):3303-3307.