The first observation of seasonal affective disorder symptoms in Rhesus macaque

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	The first observation of seasonal affective disorder symptoms in Rhesus macaque
	Qin DD[*]1,3; Chu XX[1; Feng XL 1; Li ZF 1; Yang SC 1; Lv LB 4; Yang Q 5; Pan L 6; Yin Y 6; Li JL 1
刊名	BEHAVIOURAL BRAIN RESEARCH
	2015
卷号	292 期号:X 页码:463-469
关键词	Antidepressant treatment Depression-related symptoms Rhesus macaque Seasonal affective disorder Short photoperiod
通讯作者	qindong108@163.com ; xthu@mail.kiz.ac.cn
合作状况	其它
英文摘要	Diurnal animals are a better model for seasonal affective disorder (SAD) than nocturnal ones. Previous work with diurnal rodents demonstrated that short photoperiod conditions brought about depression-like behavior. However, rodents are at a large phylogenetic distance from humans. In contrast, nonhuman primates are closely similar to humans, making them an excellent candidate for SAD model. This study made the first attempt to develop SAD in rhesus macaque (Macaca mulatta) and it was found that short photoperiod conditions could lead monkeys to display depressive-like huddling behavior, less spontaneous locomotion, as well as less reactive locomotion. In addition to these depression-related behavioral changes, the physiological abnormalities that occur in patients with SAD, such as weight loss, anhedonia and hypercortisolism, were also observed in those SAD monkeys. Moreover, antidepressant treatment could reverse all of the depression-related symptoms, including depressive-like huddling behavior, less spontaneous locomotion, less reactive locomotion, weight loss, anhedonia and hypercortisolism. For the first time, this study observed the SAD symptoms in rhesus macaque, which would provide an important platform for the understanding of the etiology of SAD as well as developing novel therapeutic interventions in the future.
收录类别	SCI
资助信息	This research was supported by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825500, 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020000), Selected Frontier Scientific Signif- icant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Founda- tion of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, 81271495), The Yun- nan Provincial Project to Attract One-hundred Exceptional Talents FromOverseas,theNaturalScienceFoundationofYunnanProvince of China (2010ZC218), and the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9371]
专题	昆明动物研究所_神经系统编码昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_表观遗传与神经退行性疾病昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China 3.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 4.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 5.Department of Nuclear Medicine, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China 6.Department of Rehabilitation Medicine, the Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650021, China
推荐引用方式 GB/T 7714	Qin DD[*],Chu XX[,Feng XL,et al. The first observation of seasonal affective disorder symptoms in Rhesus macaque[J]. BEHAVIOURAL BRAIN RESEARCH,2015,292(X):463-469.
APA	Qin DD[].,Chu XX[.,Feng XL.,Li ZF.,Yang SC.,...&Hu XT[].(2015).The first observation of seasonal affective disorder symptoms in Rhesus macaque.BEHAVIOURAL BRAIN RESEARCH,292(X),463-469.
MLA	Qin DD[*],et al."The first observation of seasonal affective disorder symptoms in Rhesus macaque".BEHAVIOURAL BRAIN RESEARCH 292.X(2015):463-469.