Association of RELN promoter SNPs with schizophrenia in the Chinese populatio

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 比较基因组学

	Association of RELN promoter SNPs with schizophrenia in the Chinese populatio
	Chang LH 1; Li M 2,3; Luo XJ 2,3; Liu XY 4; Yin LD 4; Yang SY 4; Diao HB 5; Su B[]2; Pu XF[]4
刊名	动物学研究
	2011
卷号	32 期号:5 页码:504-508
关键词	RELN Schizophrenia Promoter SNP Chinese population
通讯作者	sub@mail.kiz.ac.cn ; yxpuxingfu@gmail.com
中文摘要	精神分裂症是一种常见的复杂精神疾病。大量的实验证据表明,遗传因素在精神分裂症的发生中起到了重要的作用。截至目前,有报道称至少100个基因与精神分裂症相关,但它们在不同人群中的重复性不好。在这些基因中,RELN在多个人群中都被证实与精神分裂症相关,表明它可能是一个真实的易感基因。目前,在RELN基因上有很多个单核苷酸多态性位点被证实与精神分裂症相关,其中研究最多的是通过全基因组关联分析发现的在RELN基因第四个内含子中的单核苷酸多态性位点rs7341475,它被证明与精神分裂症的发生相关。为了验证该位点在中国人群中是否与精神分裂症相关,作者对来自中国玉溪的病例——对照样本(400位患者和400位正常人)进行了遗传分析。结果显示,在该样本中rs7341475与精神分裂症不相关,这表明rs7341475在中国人群中可能不是致病多态性位点。
英文摘要	Previous research on gene expression analysis and association tests have suggested that RELN is a risk gene for schizophrenia in world populations. Based on the reported down-regulation of RELN in schizophrenia patients compared with normal subjects, we speculated that variants in the RELN promoter region may confer risk for schizophrenia. In this study, we investigated the associations of three SNPs in the promoter region of RELN with schizophrenia in a case-control sample from southwestern China (940 cases and 1 369 controls). The results suggested that none of the SNPs showed significant associations in our sample, indicating the risk variants for schizophrenia in RELN may not be located in the promoter region. We also performed meta-analysis by combining our data with previously reported data on the Chinese population with a total sample size of 2 843 individuals, and the result remained non- significant. Collectively, our results suggested variants in the RELN promoter may not harbor risk SNPs associated with schizophrenia in the Chinese population.
收录类别	其他
语种	英语
公开日期	2011-12-20
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6846]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_神经系统疾病昆明动物研究所_转化基因组
作者单位	1.The First Affiliated Hospital of Kunming Medical College, Kunming 650032, China 2.The State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Center, the Chinese Academy of Sciences, Kunming 650223, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100101 4.The Second People's Hospital of Yuxi City, Yuxi 653101, China 5.Yunnan Mental Health Hospital, Kunming 650224, China
推荐引用方式 GB/T 7714	Chang LH,Li M,Luo XJ,et al. Association of RELN promoter SNPs with schizophrenia in the Chinese populatio[J]. 动物学研究,2011,32(5):504-508.
APA	Chang LH.,Li M.,Luo XJ.,Liu XY.,Yin LD.,...&Pu XF[*].(2011).Association of RELN promoter SNPs with schizophrenia in the Chinese populatio.动物学研究,32(5),504-508.
MLA	Chang LH,et al."Association of RELN promoter SNPs with schizophrenia in the Chinese populatio".动物学研究 32.5(2011):504-508.