Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes

	Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes
	Li X 1,5; Liang J 2; Yu HJ 3; Su B 1,4; Xiao CJ 3; Shang YF[]2; Wang W[]1,4
刊名	TRENDS IN GENETICS
	2007
卷号	23 期号:9 页码:427-431
ISSN号	0168-9525
通讯作者	yshang@hsc.pku.edu.cn ; wwang@rnail.kiz.ac.cn
合作状况	其它
英文摘要	The origin of new exons is an important mechanism for proteome diversity. Here, we report the recurrent origination of new exons in mammalian chromodomain Y-like (CDYL) genes and the functional consequences associated with the acquisition of the new exons. Driven by positive selection, the newly evolved longer peptide exhibits weaker transcription repression activity and attenuates the repression activity of the old form, suggesting that the acquisition of the new exons is functionally significant.
收录类别	SCI
资助信息	This work was supported by a CAS–Max Planck Society Fellowship, grants (30325016 and 30430400 to W.W.; 30621002, 30393113 and 30470912 to Y.S.)from the NationalNaturalScience Foundation ofChina, andgrants (863 Program: 2006AA02Z466 and 973 Program: 2005CB522404 to Y.S.) from the Ministry of Science and Technology of China.
原文出处	200723427.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/4823]
专题	昆明动物研究所_基因起源组昆明动物研究所_比较基因组学昆明动物研究所_中国科学院昆明灵长类研究中心昆明动物研究所_细胞与分子进化重点实验室
作者单位	1.CAS-Max Planck Junior Research Group, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan 650223, China 2.Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China 3.Key Laboratory of Bioresources Conservation and Utilization and Human Genetics Center of Yunnan University, Kunming 650091, China 4.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 5.Graduate School of Chinese Academy of Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Li X,Liang J,Yu HJ,et al. Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes[J]. TRENDS IN GENETICS,2007,23(9):427-431.
APA	Li X.,Liang J.,Yu HJ.,Su B.,Xiao CJ.,...&Wang W[*].(2007).Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes.TRENDS IN GENETICS,23(9),427-431.
MLA	Li X,et al."Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes".TRENDS IN GENETICS 23.9(2007):427-431.