Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 比较基因组学

	Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia
	Zhong H 1,2,5; Shi H 1; Qi XB 1; Xiao CJ 3; Jin L 4; Ma RLZ[]2; Su B[]1
刊名	JOURNAL OF HUMAN GENETICS
	2010
卷号	55 期号:7 页码:428-435
关键词	genetic divergence Out of Africa prehistoric migration Y chromosome
ISSN号	1434-5161
通讯作者	rlma@genetics.ac.cn ; sub@mail.kiz.ac.cn
合作状况	其它
英文摘要	The regional distribution of an ancient Y-chromosome haplogroup C-M130 (Hg C) in Asia provides an ideal tool of dissecting prehistoric migration events. We identified 465 Hg C individuals out of 4284 males from 140 East and Southeast Asian populations. We genotyped these Hg C individuals using 12 Y-chromosome biallelic markers and 8 commonly used Y-short tandem repeats (Y-STRs), and performed phylogeographic analysis in combination with the published data. The results show that most of the Hg C subhaplogroups have distinct geographical distribution and have undergone long-time isolation, although Hg C individuals are distributed widely across Eurasia. Furthermore, a general south-to-north and east-to-west cline of Y-STR diversity is observed with the highest diversity in Southeast Asia. The phylogeographic distribution pattern of Hg C supports a single coastal 'Out-of-Africa' route by way of the Indian subcontinent, which eventually led to the early settlement of modern humans in mainland Southeast Asia. The northward expansion of Hg C in East Asia started similar to 40 thousand of years ago (KYA) along the coastline of mainland China and reached Siberia similar to 15 KYA and finally made its way to the Americas. Journal of Human Genetics (2010) 55, 428-435; doi:10.1038/jhg.2010.40; published online 7 May 2010
学科主题	Genetics & Heredity
资助信息	This study was supported by grants from the National 973 project of China (2006CB701506, 2007CB947701 ), the Chinese Academy of Sciences (KSCX1-YW-R-34), the National Natural Science Foundation of China (30413242, 30525028, 30700445, 30630013 and 30771181), and the Natural Science Foundation of Yunnan Province of China (2007C100M).
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/2203]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, Chinese Academy of Sciences, Kunming, PR China 2.Center for Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, PR China 3.Human Genetics Centre, Yunnan University, Kunming, PR China 4.State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai, PR Chin 5.Graduate School, Chinese Academy of Sciences, Beijing, PR China
推荐引用方式 GB/T 7714	Zhong H,Shi H,Qi XB,et al. Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia[J]. JOURNAL OF HUMAN GENETICS,2010,55(7):428-435.
APA	Zhong H.,Shi H.,Qi XB.,Xiao CJ.,Jin L.,...&Su B[*].(2010).Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia.JOURNAL OF HUMAN GENETICS,55(7),428-435.
MLA	Zhong H,et al."Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia".JOURNAL OF HUMAN GENETICS 55.7(2010):428-435.